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Drug Name Classification Clinical Indication Comments
Black
5-AMINOLAEVULINIC ACID GEL (Ameluz®) Black Actinic keratosis
ABACAVIR / LAMIVUDINE (Kivexa®) Red
ABACAVIR/DOLUTEGRAVIR/LAMIVUDINE (Triumeq®) Red HIV
ABATACEPT Red Rheumatoid arthritis

In line with NICE TA 195 and NICE TA 280

ABATACEPT Red Juvenile idiopathic arthritis

In line with NICE TA 373

ABIRATERONE Red
ACAMPROSATE (UPDATED) Amber Simple Alcohol dependence
ACENOCOUMAROL Green Anticoagulation

For patients currently being treated with phenindione.

ACENOCOUMAROL Red Anticoagulation

New patients only.

ACETYLCYSTEINE (UPDATED) Black Usual interstitial pneumonitis (UIP)

Click on drug name for further details

 

ACETYLCYSTEINE (NACSYS) Black Respiratory disorder
ACETYLCYSTEINE 10% preservative free eye drops Amber Simple Ocular lubricants

Use in line with guidance
Leicestershire Guide to Prescribing Ocular Lubricants

ACITRETIN Red
ACLIDINIUM / FORMOTEROL INHALER (Duaklir Genuair®) Green COPD

NEW LABA/LAMA combination product – to be used in line with updated COPD Guidelines

ACLIDINIUM INHALER 322 micrograms Green COPD

For patients that cannot manage tiotropium handihaler

ACTIKERALL Green Actinic keratoses
ADALIMUMAB Red Rheumatoid and psoriatic arthritis; ankylosing spondylitis; refractory Crohn's disease

Added indication: Refractory Crohn’s disease

ADALIMUMAB (NEW) Red Juvenile idiopathic arthritis

In line with NICE TA 373

ADALIMUMAB Red Psoriasis

In line with NICE TA 146

ADALIMUMAB Red Hidradenitis suppurativa

In line with NICE TA 392

ADALIMUMAB Red Moderate to severe ulcerative colitis

In line with NICE TA 329

ADALIMUMAB (NEW) Red Plaque psoriasis in children

In line with NICE TA 455

ADALIMUMAB Red Behcet’s disease

Alternative to infliximab once established on therapy.
Subcutaneous  preparation able to be administered at home.

ADAPALENE / BENZOYL PEROXIDE (Epiduo®) Green Acne vulgaris
Adios® Black Herbal slimming aid
ADVASIL CONFORM® Amber Simple Hypertrophic Scars

Includes: Kelocote®, Pro-Sil®, Cica-Care®, Advasil Conform® and Mepiform®
Guidance For Use

AFATINIB Red
AFLIBERCEPT (Eylea®) (UPDATED) Red Wet age related macular degeneration. Diabetic macular oedema. Macular oedema due to central retinal vein occlusion and branch retinal vein occlusion.

Use in line with NICE TA346
NICE TA294
NICE TA305
NICE TA409

Age-Related Macular Degeneration - Dietary Supplements Black Age-related macular degeneration (AMD)

Not approved by local committee see Guideline

AGOMELATINE Amber Full SCA Depression

Full SCA

ALBIGLUTIDE (Eperzan®) Black Type 2 diabetes

Not yet reviewed

ALEMTUZUMAB Red Relapsing, remitting multiple sclerosis

In line with NICE TA 312

ALENDRONIC ACID + VITAMIN D Black Postmenopausal osteoporosis
ALENDRONIC ACID EFFERVESCENT TABLETS (Binosto®) (UPDATED) Green Osteoporosis

For patients that cannot swallow tablets.  Not suitable for administration via a feeding tube.

ALIROCUMAB Subcutaneous Injection (Praluent®) (UPDATED) Red Primary hypercholesterolaemia

In line with NICE TA 393

ALISKIREN Amber Full SCA Hypertension

Full SCA

ALITRETINOIN Red Severe chronic hand eczema

In line with NICE TA 177

ALOGLIPTIN Green Type 2 diabetes
ALPHA-1 ANTITRYPSIN (Respreeza®) (NEW) Black Emphysema in adults

Not yet reviewed

ALPROSTADIL cream (Vitaros®) (UPDATED) Black Erectile dysfunction
AMANTADINE Amber Simple Parkinson's disease

Click on drug name for further detail

AMANTADINE (NEW) Amber Simple For fatigue in Multiple sclerosis

Amantadine for fatigue in Multiple sclerosis: prescribing notes

AMIFAMPRIDINE (Firdapse®) Black Lambert-Eaton myasthenic syndrome
AMILORIDE Amber Full SCA Heart failure and hypertension in infants and children

Full SCA

AMISULPRIDE Amber Full SCA Schizophrenia

Full SCA     Request form

AMPHOTERICIN 0.15% preservative free eye drops Red
ANAGRELIDE Red
ANAKINRA Red
ANASTROZOLE Amber Simple Adjuvant therapy in early breast cancer
ANIDULAFUNGIN Black Invasive candidiasis
ANTICANCER DRUGS Red Neoplastic disease

Classified as BLACK or RED unless an exception for shared care (see this list).

ANTIPSYCHOTICS-Atypical Amber Full SCA All licensed indications, personality disorder

Full SCA

Full SCA personality disorder

ANTIRETROVIRALS Red HIV
ANTITHROMBIN recombinant Black Congenital antithrombin deficiency
APIXABAN Green Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation

Use in line with
Primary Care Initiation Pathway 
UHL Prescribers use 
UHL Initiation Pathway (Secondary Care)

APIXABAN (UPDATED) Amber Simple Treatment and secondary prevention of DVT and PE

In line with NICE TA 341

APOMORPHINE (UPDATED) Amber Full SCA Parkinson's disease

Full SCA     Request form

APRACLONIDINE Red Glaucoma
APREMILAST (Otezla®) (NEW) Red Psoriasis

In line with NICE TA 419

APREMILAST (Otezla®) (UPDATED) Red Psoriatic arthritis

In line with NICE TA 433

ARIPIPRAZOLE LONG-ACTING INJECTION (Abilify Maintena®) Amber Full SCA Maintenance treatment of schizophrenia in patients currently stabilised on oral aripiprazole

Full SCA     Request form

ARIPIPRAZOLE oral Amber Full SCA Schizophrenia. Treatment and recurrence of mania. Control of agitation and disturbed behaviour in schizophrenia

Full SCA     Request form

ASENAPINE Black Manic episodes of bipolar disorder.
ATALUREN (NEW) Red Duchenne muscular dystrophy

In line with NICE HST3

ATAZANAVIR Red
ATAZANAVIR / COBICISTAT (Evotaz®) (NEW) Red HIV infection
ATOMOXETINE Amber Full SCA Attention deficit hyperactivity disorder (ADHD)

Adults
Full SCA

Children and adolescents
Full SCA     Request form

 

ATOVAQUONE Red
ATROPINE EYE DROPS Green Conditional Palliative care in line with guidance

Palliative Care Guidelines

AVANAFIL Black Erectile dysfunction

Not yet reviewed

AVIPTADIL/PHENTOLAMINE intracavernosal injection (Invicorp®) Black Erectile dysfunction

Not yet reviewed

AXITINIB Red
AZATHIOPRINE Amber Full SCA Dermatological disease

Full SCA

AZATHIOPRINE Amber Full SCA Paediatric Inflammatory Bowel Disease (Ulcerative Colitis and Crohn's Disease)

Full SCA

 

AZATHIOPRINE Amber Full SCA Rheumatological disease

Full SCA     Request form

AZATHIOPRINE Amber Full SCA Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease) & Autoimmune Hepatitis

Full SCA

AZILSARTAN Black Hypertension
AZTREONAM Red Infection in cystic fibrosis
BALSALAZIDE Amber Full SCA Ulcerative colitis

Full SCA

BARICITINIB (Olumiant®) (UPDATED) Red Moderate-to-severe rheumatoid arthritis

In line with NICE TA 466

BECAPLERMIN Black
BECLOMETASONE DIPROPIONATE / FORMOTEROL (Fostair®) Green Asthma
COPD

Prescribe in line with Adult Asthma Guideline

BECLOMETASONE Inhaler - CFC free Green Asthma

QVAR brand recommended for adults. Clenil Modulite brand recommended only for children.

BEDAQUILINE (UPDATED) Red Multi-drug resistant tuberculosis
BETAMETHASONE plaster (Betesil®) Black Inflammatory skin disorders not responding to less potent corticosteroids

Not approved by local committee

BEXAROTENE Red
BEZLOTOXUMAB (Zinplava®) (NEW) Black Prevention of recurrence of Clostridium difficile infection

Not yet reviewed

BICALUTAMIDE Amber Simple Prostate cancer
BILASTINE Black Allergic rhinoconjunctivitis and urticaria
BIMATOPROST / TIMOLOL eye drops (Ganfort®) Green Glaucoma

If prescribed in line with Glaucoma Algorithm

BIMATOPROST / TIMOLOL preservative free eye drops (Ganfort UD®) Green Glaucoma

If prescribed in line with Glaucoma Algorithm

BIMATOPROST preservative free eye drops Green Glaucoma

If prescribed in line with Glaucoma Algorithm

Bio-Oil® Black Skincare product
BIOBRAN MGN-3 Black Adjuvant to cancer treatment

Cancer Research UK statement

BOSENTAN Red Pulmonary hypertension

Specialist centres only

BOSUTINIB Red
BOTULINUM TOXIN Red Various indications

Policy in development

BOTULINUM A TOXIN Red Chronic migraine

see NICE TA 260

BOTULINUM A TOXIN (Dysport®) (NEW) Black

Not yet reviewed

BOTULINUM A TOXIN (Xeomin®) Red As per licence
BRIMONIDINE CUTANEOUS GEL (UPDATED) Green Facial erythema of rosacea (fixed erythema not flushing)

Review after one month and discontinue if no benefit

BRINZOLAMIDE / BRIMONIDINE (Simbrinza®) eye drops Green Glaucoma

If prescribed in line with Glaucoma Prescribing Algorithm

BRINZOLAMIDE / TIMOLOL (Azarga®) Green Glaucoma

If prescribed in line with Glaucoma Prescribing Algorithm

BRIVARACETAM (NEW) Red Epilepsy (third line agent)
BROMOCRIPTINE Amber Full SCA Hyperprolactinaemic disorders

Full SCA

BUDESONIDE (Budenofalk®) Amber Simple Autoimmune hepatitis, Crohn's disease, ulcerative colitis
BUDESONIDE / FORMOTEROL INHALER (DuoResp Spiromax®) Green Asthma & COPD

Prescribe by brand as Budesonide/Formoterol devices not interchangeable. For new patients  and existing patients over 18 years after a review by a healthcare professional and counselling of patient to ensure correct use of device

BUPRENORPHINE Green Severe pain

including transdermal patch

BUSERELIN (Suprecur®) Red IVF
BUSULFAN Red
CABERGOLINE Black Parkinson's disease

Black for new patients, existing patients to remain on therapy.

CABERGOLINE (UPDATED) Amber Simple Hyperprolactinaemic disorders
CABERGOLINE (NEW) Red Suppression of lactation
CABOZANTINIB tablets (Cabometyx®) (NEW) Black Renal cell carcinoma

Not yet reviewed

CALCIPOTRIOL/BETAMETHASONE CUTANEOUS FOAM (Enstilar®) (UPDATED) Green Psoriasis vulgaris

Management of Psoriasis in Primary Care

CALCITONIN injection Red

New patients only

CANAGLIFLOZIN Amber Simple Type 2 diabetes

Click on drug name for further details

CANAGLIFLOZIN Green Conditional Type 2 diabetes

Conditional on prescriber being competent to select appropriate patients.

CANAGLIFLOZIN (NEW) Green Monotherapy in type 2 diabetes

In line with NICE TA 390

CANAGLIFLOZIN / METFORMIN (Vokanamet®) Black Type 2 diabetes

Not yet reviewed

CANNABIS Derivative (Sativex®) Black Multiple sclerosis

see East Midlands policy

CAPECITABINE Red
CAPHOSOL® Red Oral mucositis in head & neck cancer patients
CAPSAICIN 8% patch (Qutenza®) Red Peripheral neuropathic pain

Only if unresponsive to other treatments in local guidance.

CAPSAICIN 8% PATCH (Qutenza®) (NEW) Black Diabetic neuropathy
CAPTOPRIL Amber Full SCA Heart failure and hypertension in infants and children

Full SCA

CASPOFUNGIN Red
CEFIXIME Green Gonorrhoea
CEFOTAXIME Red
CEFTAROLINE Red Confirmed MRSA community acquired pneumonia and complicated skin and soft tissue infections

On advice of a consultant microbiologist only

CEFTAZIDIME Red
CEFTAZIDIME / AVIBACTAM (Zavicefta®) (NEW) Black

New formulation
Not yet reviewed

CEFUROXIME 5% eye drops Red
CELECOXIB (Onsenal®) Black Familial adenomatous polyposis
CERITINIB (Zykadia®) Black Lung cancer

Not yet reviewed

CERTOLIZUMAB PEGOL (UPDATED) Red Rheumatoid arthritis

In line with  NICE TA 375 and NICE TA 415

CERTOLIZUMAB PEGOL (UPDATED) Red Ankylosing spondylitis and non-radiographic axial spondyloarthritis

In line with NICE TA 383

CERTOLIZUMAB PEGOL (NEW) Red Psoriatic arthritis

In line with NICE TA 445

CETRORELIX (Cetrotide®) Red IVF
CHLORAMBUCIL Red
CHLORHEXIDINE 2% EYE DROPS Black Fungal keratitis

Not approved by local committee

CHLORHEXIDINE GLUCONATE 1% cream (Eczmol®) Green Adjunctive therapy for decreasing bacterial load only in cases of recurrent infected atopic eczema in children.
CHLORHEXIDINE GLUCONATE 1% cream (Eczmol®) Black Eczema and Dermatitis

Not approved by local committee

CHORIONIC GONADOTROPHIN (Pregnyl®) Red IVF
CICA-CARE® Amber Simple Hypertrophic Scars

Shared care request is not mandatory.
Simple Amber List
Includes: Kelocote®, Pro-Sil®, Cica-Care®, Advasil Conform® and Mepiform®
Guidance For Use

CICLOSPORIN OPTHALMIC EMULSION (Ikervis®) Amber Simple Dry eye disease

In line with NICE TA 369

CICLOSPORIN Oral Amber Full SCA Dermatological disease

Full SCA

CIDOFOVIR Red CMV retinitis
CINACALCET Amber Full SCA Secondary hyperparathyroidism

Shared care request is mandatory
Full SCA

CINACALCET (NEW) Red Primary hyperparathyroidism
CINNARIZINE / DIMENHYDRINATE (Arlevert®) Amber Simple Dizziness in Meniere's disease

Click on drug name for further details

CIPROFLOXACIN 0.2% preservative free eye drops Red
CIPROFLOXACIN eye ointment Green Eye infections

Second-line to chloramphenicol

CITALOPRAM Amber Simple Depressive illness in children and young people
Clindamycin plus tretinoin (Treclin®) (NEW) Green Acne

Second choice in line with local algorithm

CLOMIPHENE Red
CLOZAPINE Red

Leicestershire Partnership Trust consultants only

CO-PROXAMOL (NEW) Black Analgesia

Due to safety concerns

Cobicistat (Tybost®) Red HIV infection
COBICISTAT / ELVITEGRAVIR / EMTRICITABINE / TENOFOVIR (Stribild) Red HIV
COBIMETINIB (Cotellic®) Black Melanoma

Not yet reviewed

COLESEVELAM Black Primary and familial hypercholesterolaemia

Not yet reviewed

COLESEVELAM (UPDATED) Amber Simple Bile acid malabsorption

Off label use second line to colestyramine if that is not tolerated.

COLESTILAN Black Hyperphosphataemia with renal failure

Following local review

COLISTIMETHATE SODIUM (Colobreathe®) INHALATION POWDER Red Cystic Fibrosis
COLISTIN Red IV for cystic fibrosis
COLISTIN Amber Full SCA Pseudomonas aeruginosa lung infections (Nebulised)

Shared care request is mandatory
Full SCA (Colomycin)
Full SCA (Promixin®)

COLLAGENASE Red
COLLAGENASE CLOSTRIDIUM HISTOLYCUM (NEW) Red Dupuytrens

In Line with NICE TA 459

CORNEAL EPITHELIAL CELLS (Ex vivo expanded autologous human) containing stem cells (Holoclar®) (NEW) Red Moderate-severe limbal stem cell deficiency after eye burns

In line with NICE TA 467
Holoclar® is licensed for the treatment of adults with moderate-severe limbal stem cell deficiency (defined by the presence of superficial corneal neovascularisation in at least two corneal quadrants, with central corneal involvement, and severely impaired visual acuity

CRIZOTINIB Red
CYCLOPHOSPHAMIDE Red
DABIGATRAN (UPDATED) Amber Full SCA Venous thromboembolism (treatment and long term secondary prevention)

In line with NICE TA 327

DABIGATRAN Green Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation

Use in line with Primary Care Initiation Pathway 
UHL Prescribers use 
UHL Initiation Pathway (Secondary Care)

DABIGATRAN Red Prevention of Venous Thromboembolism (VTE) following knee / hip replacement surgery

In line with NICE  TA 157

DABRAFENIB Red
DACLATASVIR Red Hepatitis C

In line with NICE TA 364

DACLATASVIR (NEW) Red Patients with hepatitis C who have Cirrhosis

NHSE policy statement

Reviewed by TAS

DACLIZUMAB (UPDATED) Red Relapsing forms of multiple sclerosis

In line with NICE TA 441

DALBAVANCIN (Xydalba®) (NEW) Black Bacterial skin infections

Not yet reviewed

DALTEPARIN Green Conditional Thromboprophylaxis and Treatment of DVT

Conditional for those prescribers who have received the accredited training currently used in One City.Training

DALTEPARIN Amber Full SCA Thromboprophylaxis & treatment of DVT

If prescriber has not received training. Shared care request is mandatory.
Full SCA

DAPAGLIFLOZIN (NEW) Green Monotherapy in type 2 diabetes

In line with NICE TA 390

DAPAGLIFLOZIN Amber Simple Type 2 diabetes

Amber if GP does not feel competent to initiate. Use in line with NICE TA 288
Simple Amber List

DAPAGLIFLOZIN Green Conditional Type 2 diabetes

Conditional on prescriber being competent to select appropriate patients

DAPAGLIFLOZIN / METFORMIN (Xigduo®) Black Type 2 diabetes

Not yet reviewed

DAPOXETINE Black Premature ejaculation

Not yet reviewed

DAPTOMYCIN Red Complicated Gram +ve skin/soft tissue infections
DARBEPOETIN Red Anaemia of chronic kidney disease
DARIFENACIN Black Urinary incontinence/urgency
DARUNAVIR Red HIV infection
DARUNAVIR / COBICISTAT (Rezolsta®) (NEW) Red HIV infection
DASABUVIR (NEW) Red Patients with hepatitis C who have Cirrhosis

NHSE policy statement

Reviewed by TAS

DASATINIB Red
DEFERASIROX Red Iron overload
DEFERIPRONE Red
DEGARELIX Amber Simple Treatment of prostate cancer

Shared care request is not mandatory
Simple Amber List

DENOSUMAB (Prolia®) Amber Full SCA Post-menopausal osteoporosis

Full SCA

DENOSUMAB (Xgeva®) Amber Full SCA Prevention of skeletal related events in adults with bone metastases from solid tumours other than prostate

Full SCA

DENOSUMAB (Xgeva®) Red Prevention of skeletal related events in adults with bone metastases from solid tumours other than prostate

Red for patients with severe renal impairment (creatinine clearance less than 30ml/min)

DEQUALINIUM CHLORIDE VAGINAL TABLETS (Fluomizin®) Black Bacterial vaginosis
Dermatix® Black Dressing for treatment of scars
DESFERRIOXAMINE Red
DESIRUDIN Red
DEXAMETHASONE intravitreal implant (UPDATED) Red Macular oedema due to retinal vein occlusion

In line with NICE TA 229
NICE TA349

DEXAMFETAMINE Amber Full SCA Attention deficit hyperactivity disorder (ADHD)

Adults
Full SCA

Children and adolescents
Full SCA     Request form

DEXIBUPROFEN Black Pain and inflammation
DIAMORPHINE NASAL SPRAY (Ayendi®) Black Acute severe pain in children and adolescents

Not yet reviewed

DICLOFENAC GEL 3% (Solaraze®) Green Actinic keratosis
DIDANOSINE Red
DIMETHYL FUMARATE Red Multiple sclerosis

In line with  NICE TA 320

 

DINOPROSTONE Red Induction of labour
DISODIUM PAMIDRONATE Red
DISULFIRAM Amber Simple Adjunct in alcohol dependence

Shared care request is not mandatory
Simple Amber List

DOLASETRON Black Chemotherapy-induced nausea & vomiting
DOLUTEGRAVIR Red HIV
DONEPEZIL Amber Full SCA Dementia

Full SCA     Request form

DORIPENEM Black Nosocomial pneumonia, complicated intra-abdominal and urinary tract infection
DORIPENEM Red Hospital acquired/ventilator associated pneumonia
DORNASE ALFA Amber Simple Cystic fibrosis
DOXYCYCLINE Controlled release (Efracea®) Black Rosacea

Not approved by local committee

DRONEDARONE Red Atrial fibrillation

New patients only

DROPERIDOL Red Post operative nausea & vomiting

3rd line

DULAGLUTIDE (UPDATED) Amber Simple Type 2 Diabetes

If prescriber has not received specific training.

DULAGLUTIDE (UPDATED) Green Conditional Type 2 diabetes

Conditional on prescriber being trained to select and train patients – use in conjunction with updated NICE Clinical Guideline.  Once a week preparation.

DULOXETINE Green Diabetic neuropathy

To be used in conjunction with Neuropathic Pain Guidelines

DULOXETINE Green Stress incontinence
DULOXETINE Red Fibromyalgia

For use by Pain Clinic only

DUTASTERIDE / TAMSULOSIN (Combodart®) Green Benign Prostatic Hyperplasia when used in line with pathway

Green if prescribed in line with local Male LUTS pathway

EDOXABAN (UPDATED) Amber Full SCA DVT and PE

Use in line with NICE TA354

EDOXABAN Green Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation

Use in line with
NICE TA355
Primary Care Initiation Pathway
UHL Prescribers use
UHL Initiation Pathway (Secondary Care)

 

EFAVIRENZ Red
EFAVIRENZ / EMTRICITABINE / TENOFOVIR (Atripla®) Red
EFLORNITHINE Black Female facial hirsuitism

Not approved by local committee

ELBASVIR/GRAZOPREVIR (Zepatier) (NEW) Red Hepatitis C

In line with NICE TA 413

ELTROMBOPAG Red Chronic immune thrombocytopenic purpura (ITP)
ELVITEGRAVIR/COBICISTAT/EMTRICITABINE/TENOFOVIR ALAFENAMIDE (Genvoya®) (NEW) Red HIV infection
EMPAGLIFLOZIN (NEW) Green Monotherapy in type 2 diabetes

In line with NICE TA 390

EMPAGLIFLOZIN Amber Simple Type 2 diabetes

Amber if GP does not feel competent to initiate.
Use in line with NICE TA336
Simple Amber List

EMPAGLIFLOZIN Green Conditional Type 2 diabetes

Conditional on prescriber being competent to select appropriate patients

EMPAGLIFLOZIN / LINAGLIPTIN (Glyxambi®) (NEW) Black Type 2 diabetes mellitus in adults

New formulation
Not yet reviewed

EMPAGLIFLOZIN/METFORMIN (Synjardy®) Black Type 2 diabetes

Not yet reviewed

EMTRICITABINE Red
EMTRICITABINE / RILPIVIRINE / TENOFOVIR (Eviplera®) Red
EMTRICITABINE / RILPIVIRINE / TENOFOVIR ALAFENAMIDE (Odefsey®) (UPDATED) Red HIV infection
EMTRICITABINE/TENOFOVIR ALAFENAMIDE (Descovy®) (NEW) Red HIV infection
ENALAPRIL Amber Full SCA Heart failure and hypertension in infants and children

Full SCA

ENFUVIRTIDE Red
ENOXAPARIN Red Acute coronary syndrome
ENTACAPONE Amber Simple Parkinson's disease

Click on drug name for further details

ENTECAVIR Red Chronic hepatitis B
EPISIL® Red Oral mucositis in paediatric patients following chemotherapy
EPLERENONE Green Post myocardial infarction with proven LVH
EPOETIN DELTA Black Anaemia of renal failure
EPOETIN intravenous Red

HDU

EPOETIN subcutaneous Red Anaemia of Chronic Kidney Disease
ERDOSTEINE Black Mucolytic - acute exacerbation of chronic bronchitis

Not approved by local committee

ERLOTINIB Red
ERTAPENEM Red Resistant Gram negative infections (ESBL)
ERTAPENEM IV (NEW) Green Extended Spectrum Beta Lactamase (ESBL) Urinary Tract Infection (UTI)

UTI in line with Primary care ESBL Guidance

ESCITALOPRAM Black All indications except treatment resistant depression and generalised anxiety disorder

Not approved by local committee

ESCITALOPRAM (UPDATED) Green Treatment resistant depression and generalised anxiety disorder
ESLICARBAZEPINE (UPDATED) Amber Simple Treatment resistant epilepsy
ESTRADIOL / NOMEGESTROL (Zoely®) Black Combined oral contraceptive
ESTRAMUSTINE Red
ETANERCEPT (NEW) Red Juvenile idiopathic arthritis

In line with NICE TA 373

ETANERCEPT (NEW) Red Plaque psoriasis in children

In line with NICE TA 455

ETANERCEPT Red DMARD for RA, including weekly SC injection
ETANERCEPT Red Plaque psoriasis

In line with NICE TA103

ETELCALCETIDE injection (Parsabiv) (UPDATED) Red Secondary hyperparathyroidism in adult patients with chronic kidney disease on haemodialysis therapy

Inline with NICE TA 448

ETHINYLESTRADIOL / DESOGESTREL (Alenvona®) Black Oral contraceptive

Not yet reviewed

ETOPOSIDE Red
ETRAVIRINE Red
EVENING PRIMROSE OIL (GAMOLENIC ACID) (Epogam® or Efamast®) (NEW) Black Cyclical breast pain/mastalgia. Atopic eczema

No evidence to support use for these indications.
Marketing authorisations were withdrawn in 2002

EVEROLIMUS Red Angiomyolipomas associated with tuberous sclerosis
EVOLOCUMAB subcutaneous injection (Repatha®) (UPDATED) Red Primary hypercholesterolaemia or mixed dyslipidaemia

In line with NICE TA 394

EVRA® patch Green Contraception
EXEMESTANE Amber Simple Adjuvant therapy in early breast cancer
EXENATIDE (UPDATED) Amber Simple Type 2 Diabetes

If prescriber has not received specific training. Simple Amber List
To be used in line with NICE Guidelines CG66
Once a week preparation (Bydureon®) is formulary.
Twice daily preparation (Byetta®) is non-formulary. However, existing patients may remain on treatment.

EXENATIDE Green Conditional Type 2 diabetes

Once a week preparation (Bydureon®) is formulary. Conditional on prescriber being trained to select and train patients. Use in conjunction with Updated Nice Clinical Guideline.

————————-

Twice daily preparation (Byetta®) is non formulary. However, existing  patients may remain on treatment

EZETIMIBE Green
EZETIMIBE + SIMVASTATIN (Inegy®) Black Hypercholesterolaemia
FAMPRIDINE Black Multiple Sclerosis
FEBUXOSTAT Green Gout (2nd line after allopurinol)

In line with NICE TA 164

FENTANYL BUCCAL FILM (Breakyl®) Black Breakthrough cancer pain in patients already on opioids

Not yet reviewed

FENTANYL intranasal spray Black Breakthrough cancer pain
FENTANYL Sublingual (Abstral®) Green Conditional Breakthrough cancer pain in patients already on opioids. Palliative care in line with guidance

Conditional on recommendation from palliative care team.
See: Palliative care – drugs for use only after specialist recommendation

FENTANYL TRANSDERMAL SYSTEM (IONSYS®) Black Post-operative pain
FENTICONAZOLE Black Vulvovaginal candidiasis
FERUMOXYTOL INJECTION (Rienso®) Black Iron deficiency anaemia in chronic kidney disease
FESOTERODINE Black Urinary frequency
FIBRINOGEN CONCENTRATE (Human) (FibCLOT®) (NEW) Black Treatment and perioperative prophylaxis of bleeding in patients with congenital hypo- or afibrinogenaemia with bleeding tendency

New formulation
Not yet reviewed

FIDAXOMICIN Amber Simple Clostridium difficile infection

GP can initiate if in line with Community Clostridium difficile Care Pathway

FILGRASTIM Red
FINGOLIMOD Red Multiple Sclerosis

NICE supported.
EMSCG funding.

FLUDARABINE Red
FLUNARIZINE (NEW) Red Migraine prophylaxis in adults
FLUNARIZINE Red Alternating hemiplegia/refractory migraine in children

Unlicensed

FLUOCINOLONE ACETONIDE (Iluvien®) intravitreal implant Red Diabetic macular oedema

In line with NICE TA301

FLUOXETINE Amber Simple Depressive illness in children and young people
FLUPENTIXOL (oral) (NEW) Green Conditional Schizophrenia and other psychoses

If used for schizophrenia or psychoses to be initiated only after diagnosis and advice to use this typical antipsychotic has been discussed with specialist

FLUPENTIXOL DECANOATE Amber Full SCA Schizophrenia

Full SCA     Request form

FLUPHENAZINE DECANOATE Amber Full SCA Schizophrenia

Full SCA     Request form

FLUTICASONE / AZELASTINE NASAL SPRAY (Dymista®) (UPDATED) Green Rhinitis

To be used in line with the Allergic Rhinitis Pathway

FLUTICASONE / FORMOTEROL INHALER (Flutiform®) (UPDATED) Black Asthma

Reviewed by LLR Respiratory Prescribing Group, deemed not appropriate for review by TAS

FLUTICASONE / VILANTEROL INHALER (Relvar®) (UPDATED) Black Asthma

Reviewed by LLR Respiratory Prescribing Group, deemed not appropriate for review by TAS

FLUTICASONE FUROATE (Avamys®) Green Allergic rhinitis
FLUTICASONE/ SALMETEROL XINAFOATE INHALER (AirFluSal Forspiro®) (NEW) Black COPD and Asthma

Reviewed by LLR Respiratory Prescribing Group, deemed not appropriate for review by TAS

FOLINIC ACID Red
FOLLITROPHIN alfa (Gonal-F®) Red IVF
FONDAPARINUX Red Heparin Induced Thrombocytopenia (HIT)
FOSAMPRENAVIR Red
FOSFOMYCIN IV (NEW) Red Only in line with advice from UHL microbiology

Please note that there is a separate traffic light entry for oral Fosfomycin.

FOSFOMYCIN Oral (NEW) Green Extended Spectrum Beta Lactamase (ESBL) Urinary Tract Infection (UTI)

UTI in line with Primary care ESBL Guidance.

FreeStyle Libre Black Glucose Monitoring System
FULVESTRANT Amber Simple Oestrogen receptor positive metastatic or locally advanced breast cancer in post menopausal women in whom disease progresses or relapses while on or after other anti oestrogen therapy

Secondary care will administer first three doses.
Shared care request is not mandatory
Simple Amber List

FUROSEMIDE Amber Full SCA Heart failure and hypertension in infants and children

Full SCA

GABAPENTIN Green Neuropathic pain

To be used in conjunction with

Neuropathic Pain Guidelines

GALANTAMINE Red Alzheimer's disease

Leicestershire Partnership Trust consultants only

GAMMAGLOBULIN Red
GANCICLOVIR Red
GANCICLOVIR 0.15% EYE GEL Black Acute herpetic keratitis

Only GREEN whilst Aciclovir eye ointment 3% is not available. Definite diagnosis only.To be used in line with local guidance Ganciclovir 0.15% eye gel

GEFITINIB Red
GENTAMICIN Red IV and inhalation
GENTAMICIN 1.5% preservative free eye drops Red
GLATIRAMER Red Multiple sclerosis

Not supported by NICE but supported by DoH.

GLUCODRATE® (NEW) Amber Simple High Output Stoma (HOS)
GLUCOSAMINE Black Osteoarthritis

In line with LMSG Glucosamine for OA Guidelines

GLYCERYL TRINITRATE Ointment 0.4% Green Anal fissure
GLYCOPROTEIN IIb/IIIa inhibitors Red
GLYCOPYRRONIUM (Sialanar®) (NEW) Black Persistent drooling in children and adolescents with neurological conditions, such as cerebral palsy, epilepsy and neurodegenerative diseases

New formulation
Not yet reviewed

GLYCOPYRRONIUM BROMIDE oral solution 1mg/5ml (NEW) Black Peptic ulcer (add-on therapy)

Not yet reviewed

GLYCOPYRRONIUM INHALER (Seebri Breezhaler®) Black COPD

Following review by LLR Respiratory Prescribing Group and Therapeutic Advisory Service

GOLD salts (UPDATED) Red Rheumatoid arthritis

Red for new patients

Full SCA to remain for existing patients

GOLIMUMAB Red Psoriatic arthritis (PA) and Rheumatoid arthritis(RA)in line with NICE guidance

PA see NICE TA 220
RA see NICE TA 225

GOLIMUMAB Red Ankylosing spondylitis

In line with NICE TA 233

GOLIMUMAB (NEW) Red Moderate to severe active ulcerative colitis

In line with NICE TA 329

GONADORELIN ANALOGUES Green Prostate cancer

GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician.

GONADORELIN ANALOGUES (NEW) Amber Simple Gender reassignment

Must be prescribed in line with recommendations from specialist. The nearest specialist is Nottingham.
Shared care request is not mandatory
Simple Amber List

GOSERELIN Green Prostatic carcinoma

GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician.

Local guidance

GOSERELIN Amber Simple Endometriosis, uterine fibroids
GOSERELIN 3.6mg (Zoladex®) (NEW) Amber Simple Breast cancer

Zoladex 3.6mg implant is the only licensed product for breast cancer

GRANISETRON Black Chemotherapy-induced nausea
GRANISETRON oral and injection Green Conditional Palliative care in line with guidance

Conditional on recommendation from palliative care team.
See: Palliative care – drugs for use only after specialist recommendation

GRANISETRON patch Black Chemotherapy-induced nausea

Not yet reviewed

GRASS POLLEN ALLERGEN EXTRACT subcutaneous injection (Pollinex®) (NEW) Red Grass pollen allergies
GRASS POLLEN ALLERGEN EXTRACT sublingual (Grazax®) Amber Full SCA Grass pollen allergies

Full SCA

GUANFACINE (NEW) Amber Full SCA ADHD (click on drug name for more info)

Full SCA     Request form

 

HALOPERIDOL (oral) (NEW) Green Conditional Schizophrenia and psychoses

If used for schizophrenia or psychoses to be initiated only after diagnosis and advice to use typical antipsychotic has been discussed with specialist

HALOPERIDOL DECANOATE Amber Full SCA Schizophrenia

Full SCA     Request form

HEPARIN Red Full IV anticoagulation
HEPARIN SODIUM FLUSH (NEW) Green Flushing solution for maintenance of patency of intravenous devices
HEPATITIS C treatments Red
HERBAL MEDICINES that are unregistered (NEW) Black

Not approved by local committee

HERBAL MEDICINES with a Marketing Authorisation (NEW) Black

Reviewed upon request by a consultant or GP prescribing lead

HERBAL MEDICINES with a Traditional Herbal Registration (NEW) Black

Not approved by local committee

HOMEOPATHIC MEDICINES Black

Not approved by local committee see Position Statement

HYALURONIC ACID DERIVATIVE (Synvisc®) Black Black in all indications EXCEPT for pain relief in osteoarthritis of shoulder joint (RED)
HYALURONIC ACID DERIVATIVE (Synvisc®) Red Pain relief in osteoarthritis of shoulder joint.
HYDROCORTISONE 1% / OXYTETRACYCLINE 3% (Terra-Cortril®) Black Overgranulation of wounds

Not approved by local committee

HYDROCORTISONE modified release (Plenadren®) Black Hypoadrenalism (once daily dose)
HYDROXYCARBAMIDE Amber Full SCA Myeloproliferative disorders

Full SCA

HYDROXYCHLOROQUINE Amber Full SCA Rheumatological disease

Full SCA     Request form

IBANDRONIC ACID - IV Red Postmenopausal osteoporosis
IBANDRONIC ACID - Oral Amber Simple Breast cancer bone metastases

Shared care request is not mandatory
Simple Amber List

IBANDRONIC ACID Oral monthly Green Postmenopausal osteoporosis

Use only when compliance with oral therapy is an issue

ICATIBANT acetate (UPDATED) Red Hereditary angioedema
IDARUBICIN Red
IDARUCIZUMAB (Praxbind) Red Reversal of severe bleeding due to dabigatran
IDEBENONE (Raxone®) (NEW) Black Leber’s hereditary optic neuropathy

Not yet reviewed

IDELALISIB Red
IDURSULFASE Black Hunter syndrome (mucopolysaccharidosis II)
IMATINIB Red
IMIPENEM Red
IMIQUIMOD CREAM 3.75% (Zyclara®) Black Actinic keratosis of face and scalp
IMIQUIMOD cream 5% (Aldara®) Red Basal cell carcinoma
IMIQUIMOD cream 5% (Aldara®) (NEW) Green Actinic keratoses

In line with Actinic Keratoses treatment pathway

IMMUNOGLOBULINS Red
INDACATEROL (Breezhaler®) (UPDATED) Black COPD

Reviewed by LLR Respiratory Prescribing Group, deemed not appropriate for review by TAS

INDACATEROL / GLYCOPYRRONIUM INHALER (Ultibro Breezhaler®) (UPDATED) Black COPD

Reviewed by LLR Respiratory Prescribing Group, deemed not appropriate for review by TAS

INDINAVIR Black
INFLIXIMAB Red All indications
INGENOL MEBUTATE GEL (Picato®) (UPDATED) Green Actinic keratosis (non hypertrophic)

Actinic Keratoses (AK) Treatment Pathway

INSULIN ASPART (Fiasp®) (NEW) Black Type 1 and 2 diabetes mellitus in adults

New formulation
Not yet reviewed

INSULIN DEGLUDEC (Tresiba®) Green Conditional Diabetes mellitus in adults

Conditional on prescriber being trained to select appropriate patients
MUST BE PRESCRIBED BY BRAND NAME

INSULIN DEGLUDEC (Tresiba®) Amber Simple Diabetes mellitus in adults

Shared care request is not mandatory.  Simple amber if prescriber has not received specific training.
Simple Amber List
MUST BE PRESCRIBED BY BRAND NAME

INSULIN DEGLUDEC / LIRAGLUTIDE (combination product) (Xultophy®) (NEW) Green Conditional Diabetes

Conditional on prescriber being trained to select and train patients.

INSULIN DEGLUDEC/LIRAGLUTIDE (combination product) (Xultophy®) (NEW) Amber Simple Diabetes

Shared care request is not mandatory

For those who have not had the training.
Simple Amber List

INSULIN GLARGINE (Toujeo® 300units per ml) (UPDATED) Green Diabetes mellitus in adults

UKMI – Product Safety Assessment Report
MUST BE PRESCRIBED BY BRAND NAME

INSULIN GLARGINE / LIXISENATIDE (Suliqua®) (NEW) Black Type 2 diabetes mellitus in adults

New formulation
Not yet reviewed

INSULIN GLULISINE (Apidra®) Green Type 1 and 2 diabetes

Prescribe by brand name to avoid confusion with insulin glargine.

INSULIN LISPRO (Humalog®) U200 (NEW) Green Conditional Diabetes Mellitus

Conditional on prescriber being competent to select appropriate patients

INSULIN LISPRO (Humalog®) U200 (NEW) Amber Simple Diabetes Mellitus

Amber if GP does not feel competent to initiate.

INTERFERON ALFA Red
INTERFERON BETA Red
IRON(III) ISOMALTOSIDE 1000 (Diafer®) (NEW) Red Iron deficiency (renal use only)
ISAVUCONAZOLE (NEW) Red Invasive aspergillosis and mucormycosis
ISOTRETINOIN - Oral Red Severe acne
ISOTRETINOIN - Topical Green Mild-moderate acne
IVABRADINE Green Chronic stable angina

For patients who cannot tolerate beta blockers

IVABRADINE Amber Simple Chronic heart failure
IVACAFTOR Red Cystic fibrosis
IVERMECTIN CREAM Green Moderate to severe papulo-pustula rosacea
IXEKIZUMAB (NEW) Red Psoriasis

In line with NICE TA 442

KELO-COTE® Amber Simple Hypertrophic Scars

Shared care request is not mandatory
Simple Amber List
Includes: Kelocote®, Pro-Sil®, Cica-Care®, Advasil Conform® and Mepiform®
Guidance For Use

KETAMINE Green Conditional Palliative Care

Conditional on recommendation from palliative care team.

See: Palliative care – drugs for use only after specialist recommendation

 

KETOCONAZOLE TABLETS Black Fungal infections

Risk of hepatotoxicity outweighs benefit
MHRA alert

KETOPROFEN / OMEPRAZOLE (Axorid®) Black Pain and inflammation for patients at risk of NSAID associated ulcers
KETOROLAC Green Conditional Palliative Care

Conditional on recommendation from palliative care team.

See: Palliative care – drugs for use only after specialist recommendation

Klean-Prep® Red Bowel cleansing
LACOSAMIDE Amber Simple Resistant epilepsy

Shared care request is not mandatory
Simple Amber List

LAMIVUDINE Red
LAMIVUDINE / ZIDOVUDINE Red
LANREOTIDE (UPDATED) Red Neuroendocrine tumours
LANREOTIDE Red Acromegaly

New patients only

LANREOTIDE Green Conditional Palliative Care

Link to Palliative Care Guidelines

LANTHANUM CARBONATE Amber Simple Hyperphosphataemia with renal failure

Shared care request is not mandatory
Simple Amber List

LAPATINIB Red
LATANOPROST preservative free eye drops Green Glaucoma

If prescribed in line with Glaucoma Prescribing Algorithm

LECICARBON A® suppositories Black Laxative or bowel preparation

Not yet reviewed

LEDIPASVIR/SOFOSBUVIR (Harvoni®) Red Hepatitis C

In line with NICE TA 363

LEFLUNOMIDE Amber Full SCA Rheumatological disease

Full SCA     Request form

LENOGRASTIM Red
LENVATINIB tablets (Kisplyx®) (NEW) Black Renal cell carcinoma
LETROZOLE Amber Simple Adjuvant therapy in early breast cancer
LEUPRORELIN Amber Simple Endometriosis, uterine fibroids
LEUPRORELIN Green Prostate cancer (subcutaneous injection for patients at risk of haematoma)

GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician.

Local guidance

LEVETIRACETAM - IV Red Epilepsy

Restricted to patients who are already maintained on the oral preparation

LEVETIRACETAM - Oral Amber Simple Epilepsy

Shared care request is not mandatory
Simple Amber List

LEVODOPA/CARBIDOPA infusion (Duodopa) Red Parkinson's disease

Treatment algorithm

Specialist centres only

LEVOFLOXACIN Eyedrops - unpreserved Red Bacterial keratitis
LEVOFLOXACIN NEBULISER SOLUTION (Quinsair®) (NEW) Black Cystic fibrosis

Not yet reviewed

LEVONORGESTREL-RELEASING INTRAUTERINE SYSTEM (Levosert®) (NEW) Black Contraception or heavy menstrual bleeding

Following local review

LIDOCAINE patch Green Postherpetic neuralgia

To be used in conjunction with Neuropathic Pain Guidelines

LIDOCAINE patch Green Focal neuropathic pain

To be used in conjunction with Neuropathic Pain Guidelines

LIDOCAINE/PRILOCAINE cutaneous spray (Fortacin) (NEW) Black Primary premature ejaculation

Not yet reviewed

LINACLOTIDE (UPDATED) Green Moderate to severe irritable bowel syndrome with constipation

Links to IBS Pathway

LINAGLIPTIN Green Type 2 Diabetes
LIOTHYRONINE (NEW) (UPDATED) Red Concomitant therapy with thyroxine

For patients who have hypothyroidism who have had inadequate response to thyroxine alone, in line with guidance

LIPEGFILGRASTIM Black Chemotherapy-induced neutropenia

Not yet reviewed locally

LIRAGLUTIDE Green Conditional Type 2 diabetes

For patients unable to tolerate lixisenatide. Conditional on prescriber being trained to select and train patients – Use in conjunction with Updated NICE Clinical Guideline

LIRAGLUTIDE (UPDATED) Amber Simple Type 2 diabetes

If prescriber has not received specific training.

Simple Amber List

LIRAGLUTIDE (Saxenda®) (NEW) Black Obesity in type 2 diabetes

Not yet reviewed

LISDEXAMFETAMINE DIMESYLATE Amber Full SCA ADHD when response to methylphenidate is inadequate

Adults
Full SCA

Children and adolescents
Full SCA     Request form

LISINOPRIL Amber Full SCA Heart failure and hypertension in infants and children

Full SCA

LITHIUM SALTS Amber Full SCA Mania, Bipolar Disorder, Recurrent Depression or Aggressive or Self-mutilating behaviour.

Full SCA     Request form

LIXISENATIDE Green Conditional Type 2 diabetes

Conditional on prescriber being trained to select and train patients

LIXISENATIDE (UPDATED) Amber Simple Type 2 diabetes

If prescriber has not received specific training.

Simple Amber List

LOMITAPIDE Black Homozygous familial hypercholesterolaemia

Not yet reviewed

LOMUSTINE Red
LOPINAVIR / RITONAVIR (Kaletra®) Red
LOSARTAN Amber Full SCA Heart failure and hypertension in infants and children

Full SCA

LOTEPREDNOL eye drops (Lotemax®) (NEW) Red Post-operative inflammation following ocular surgery
LOXAPINE inhalation powder (Adasuve®) (NEW) Black Rapid control of mild-moderate agitation in schizophrenia or bipolar disorder

Not yet reviewed

LUBIPROSTONE (UPDATED) Green Conditional Chronic refractory constipation

To be used in line with
Chronic Constipation Pathway

Chronic Constipation Training

LUMACAFTOR /IVACAFTOR (Orkambi®) Black Cystic fibrosis

Not supported by NICE

LURASIDONE Black Psychosis

Following LPT Prescribing Group review

LURASIDONE (NEW) Red Schizophrenia in adults aged 18 years and over.

For use only in those:-
Who do not respond to aripiprazole.
Who do not tolerate aripiprazole.
Who are not suitable for clozapine.

MacuLEH Light® (NEW) Black Age-related macular degeneration

Not approved by local committee see Guideline

MAGNESIUM ASPARTATE DIHYDRATE (Magnaspartate®) (NEW) Amber Simple Magnesium deficiency

Licensed  preparation now available. This will be used in preference to any unlicensed preparations. Simple Amber List

MANNITOL dry powder inhaler Red Cystic fibrosis
MARAVIROC Red
MEDROXYPROGESTERONE ACETATE DEPOT INJECTION (Sayana Press®) (UPDATED) Green Long-term contraception
MELATONIN Black Primary insomnia in adults. Circadian asynchrony in elderly institutionalised patients
MELATONIN Amber Simple Free running circadian rhythm and delayed sleep phase syndrome

Shared care request is not mandatory
Simple Amber List

MELATONIN Red Learning disability. Huntington's disease. Parkinson's disease.
MELATONIN Red Acute circadian asynchrony in hospitalised patients on ITU, HDU and other care areas
MELATONIN (doses of 10mg daily or less) Amber Simple Sleep disorders children (see comments) continued in adults if proven efficacy in childhood

Sleep onset insomnia and delayed sleep phase syndrome

Shared care request is not mandatory
LMSG guidance

Simple Amber List

MELATONIN (doses over 10mg daily) Red Sleep disorders children (see comments), continued in adults if proven efficacy in childhood

Sleep onset insomnia and delayed sleep phase syndrome in children

MELPHALAN Red
MEMANTINE Amber Full SCA Dementia

Full SCA     Request form

MENOTROPHIN (Menopur®) Red IVF
MEPIFORM® Amber Simple Hypertrophic Scars

Shared care request is not mandatory
Simple Amber List
Includes: Kelocote®, Pro-Sil®, Cica-Care®, Advasil Conform® and Mepiform®
Guidance For Use

MERCAPTAMINE (Cystadrops®) (NEW) Black Corneal cystine crystal deposits in patients aged ≥ two years with cystinosis

New formulation
Not yet reviewed

MERCAPTOPURINE Amber Full SCA Paediatric Inflammatory Bowel Disease (Ulcerative Colitis and Crohn's Disease)

Full SCA

MERCAPTOPURINE Red Leukaemia
MERCAPTOPURINE Amber Full SCA Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease) & Autoimmune Hepatitis

Full SCA

MEROPENEM Red
MESALAZINE (Mezavant® XL) Black Ulcerative colitis

Not supported by local committee

MESALAZINE ORAL (prescribe by brand) Amber Full SCA Ulcerative colitis and Crohn's disease

Full SCA

MESALAZINE RECTAL Amber Simple Ulcerative colitis and Crohn's disease
METHADONE 10mg/1ml Black All indications

This is to prevent dosing errors. The 1mg/1ml strength remains available.

METHADONE 1mg/1ml Green Conditional Palliative care in line with guidance.

Conditional on recommendation from palliative care team.
See: Palliative care – drugs for use only after specialist recommendation

METHOTREXATE Injection Red
METHOTREXATE Oral Amber Full SCA Rheumatological disease

Full SCA     Request form

METHOTREXATE Oral Amber Full SCA Dermatological disease

Full SCA

METHOTREXATE Oral Red Severe refractory asthma
METHOTREXATE Oral Amber Full SCA Crohn's Disease

Full SCA

METHYLNATREXONE Green Conditional Palliative care in line with guidance.

Conditional on recommendation from palliative care team.
See: Palliative care – drugs for use only after specialist recommendation

METHYLPHENIDATE Green Conditional Palliative care in line with guidance

Conditional on recommendation from palliative care team.
See: Palliative care – drugs for use only after specialist recommendation

METHYLPHENIDATE (+'CR') Amber Full SCA Attention deficit hyperactivity disorder (ADHD)- prescribe CR formulation by brand name only

Adults
Full SCA

Children and adolescents
Full SCA     Request form

MEXILETINE Red Ventricular arrhythmia

New patients. Existing prescribing in primary care to continue.

MIANSERIN Amber Full SCA Depression

Full SCA     Request form

MIDAZOLAM (Buccolam®) Amber Simple Status epilepticus
MIDAZOLAM buccal Green Conditional Palliative care in line with guidance.

Conditional on recommendation from palliative care team.

See: Palliative care – drugs for use only after specialist recommendation

MIDODRINE (NEW) Amber Simple Severe orthostatic hypotension

Licensed product now available

MIFEPRISTONE Red
MIGLUSTAT Black Niemann-Pick type C disease
MIRABEGRON Green Symptoms of urinary frequency, urgency and urge incontinence

In line with Overactive Bladder Pathway

MITOTANE Red
MODAFINIL Amber Full SCA Daytime sleepiness associated with Narcolepsy and existing patients being treated for Daytime Sleepiness associated with Obstructive Sleep Apnoea Syndrome, Idiopathic Hypersomnia & Shift Work Sleep Disorder.

Full SCA

MOLLUDAB® Black Molluscum contagiosum

Not yet reviewed.

MOLOGRAMOSTIN Red
MOLUTREX® Black Molluscum contagiosum

Not yet reviewed

MOVICOL liquid® Black Constipation
MOVICOL® ready to take solution in sachet (NEW) Black Constipation

Not yet reviewed

Moviprep® Red Prior to endoscopy

3rd line if intolerant to Klean Prep®

MOXIFLOXACIN Red Multi-drug resistant tuberculosis
MOXIFLOXACIN Black Respiratory tract infections (general)
MUCODIS® Red Oral mucositis in head & neck cancer patients
MYCOPHENOLATE Amber Full SCA Immunosuppression following renal transplantation

Full SCA

NABILONE Black Chemotherapy induced nausea and vomiting
NABILONE Red
NALMEFENE Green Alcohol dependence

In line with NICE TA 325

NALOXEGOL (NEW) Green Opiod induced constipation

In line with NICE TA345

Laxative Algorithm

NALTREXONE Red Pruritus in liver disease

Unlicensed indication

NALTREXONE (NEW) Amber Simple Opioid dependence

To be initiated by specialists for maintenance treatment to help prevent relapse in opioid dependence.

NICE TA 115

NAPROXEN / ESOMEPRAZOLE (Vimovo®) Black Osteoarthritis, RA & ankylosing spondylitis
NATALIZUMAB Red Rapidly evolving relapsing-remitting multiple sclerosis
Natamycin 5% eye drops (UPDATED) Red Fungal keratitis (moulds only)
NEBIVOLOL Green Hypertension

Black for all other indications

NEBIVOLOL Black All indications excluding hypertension (Green)
NELFINAVIR Black
NETUPITANT/PALONOSETRON capsules (Akynzeo®) Black Prevention of nausea and vomiting associated with chemotherapy

Not yet reviewed

NEVIRAPINE Red
NILOTINIB Red
NINTEDANIB (Ofev®) Red Idiopathic Pulmonary Fibrosis

In line with NICE TA 379

NINTEDANIB (Vargatef®) Black Lung cancer

Not yet reviewed

NUVARING® Green Contraception
OBETICHOLIC ACID (NEW) Red Primary Biliary cholangitis

In line with NICE TA 443

OCRIPLASMIN INJECTION (Jetrea®) Red Vitreomacular traction
OCTREOTIDE Red Acromegaly

New patients only

OCTREOTIDE Red GEP tumours and post-pancreatic surgery
OCTREOTIDE Green Conditional Palliative care in line with guidance

Conditional on recommendation from palliative care team.
See: Palliative care – drugs for use only after specialist recommendation

OLANZAPINE Green Conditional Palliative care in line with guidance

Conditional on recommendation from palliative care team.
See: Palliative care – drugs for use only after specialist recommendation

OLANZAPINE Oral Amber Full SCA Schizophrenia. Combination therapy for mania. Preventing recurrence in bipolar disorder. Monotherapy for mania. Control of agitation and disturbed behaviour in schizophrenia or mania. Personality disorder.

Full SCA

Full SCA personality disorder

OLANZAPINE PAMOATE MONOHYDRATE (Zypadhera®) Red Schizophrenia

Requires case by case consideration by Prescribing Group

OLMESARTAN/AMLODIPINE/HYDROCHLOROTHIAZIDE (Sevikar HCT) (NEW) Black Non-adherence due to polypharmacy
OLODATEROL INHALER Black COPD

Not yet reviewed

OLOPATADINE Green Hay fever
OMALIZUMAB Red Asthma

In line with NICE TA 278

OMALIZUMAB (NEW) Red Chronic spontaneous urticaria

NICE TA 339

OMBITASVIR/PARAPREVIR/RITONAVIR (Viekirax®) Red Hepatitis C

In line with NICE TA 365 (with or without dasabuvir)

OMEGA-3 ACID ETHYL ESTERS (Dualtis®) Black Secondary prevention of MI, hypertriglyceridaemia

Not yet reviewed

OMEGA-3 ACID ETHYL ESTERS (Omacor®) Amber Simple Hypertriglyceridaemia

Shared care request is not mandatory
Simple Amber List

OMEGA-3 ACID ETHYL ESTERS (Omacor®) Black Secondary prevention of MI

Contains Omega-3 acid ethyl esters

ONDANSETRON Green Conditional Palliative care in line with guidance

Conditional on recommendation from palliative care team.
See: Palliative care – drugs for use only after specialist recommendation

ONDANSETRON Red Hyperemesis in pregnancy
Chemotherapy/radiotherapy induced nausea
OPICAPONE capsules (Ongentys®) (NEW) Black Parkinson's disease

Not yet reviewed

ORLISTAT Green
OSIMERTINIB (Tagrisso®) Black Non-small-cell lung cancer
OSVAREN® (previously known as REPHOREN®) Amber Simple Hyperphosphataemia
OXYBUPROCAINE HYDROCORTISONE Red Local anaesthetic
OXYBUTYNIN patch Green Symptomatic treatment of urge incontinence in unstable bladder

For use only in patients who cannot take oral medication See Overactive bladder pathway

OXYCODONE / NALOXONE (Targinact®) Amber Simple Severe pain in patients with opioid-induced bowel dysfunction
OXYCODONE HYDROCHLORIDE / NALOXONE (combination product) prolonged release tablet (Targinact®) (NEW) Black Post colorectal surgery

Reviewed by TAS – No evidence to support use for this indication.

PALIPERIDONE PALMITATE Long-Acting Injection Amber Full SCA Maintenance in schizophrenia in patients previously responsive to risperidone.

Full SCA     Request form

PALIVIZUMAB Red
PALONOSETRON Black Nausea and vomiting with chemotherapy
PARACALCITOL Black Secondary hyperparathyroidism in renal failure
PARATHYROID HORMONE (Natpar®) Black Chronic Hypoparathyroidism
PASIREOTIDE subcutaneous injection (Signifor®) Black Cushing’s disease

Not yet reviewed

PAZOPANIB Red
PEGLOTICASE Black Gout

Not supported by NICE

PENICILLAMINE (NEW) Red Wilson's disease
PENICILLAMINE Amber Full SCA Rheumatoid arthritis

Full SCA     Request form

PERAMPANEL (Fycompa®) (UPDATED) Amber Simple Refractory epilepsy
PERGOLIDE Amber Simple Parkinson's disease

Click on drug name for further details

PIMECROLIMUS cream Green Dermatitis
PIRFENIDONE (Esbriet®) Red Idiopathic pulmonary fibrosis

Supported only in line with NICE TA 282

PITRESSIN Red Myomectomy
PIVMECILLINAM (NEW) Green Extended Spectrum Beta Lactamase (ESBL) Urinary Tract Infection (UTI)

UTI in line with Primary care ESBL Guidance

POLIHEXANIDE 0.02% eye drops Red
Pollinex Quattro (NEW) Black Severe hayfever caused by tree & grass pollen
POMALIDOMIDE Red
PONATINIB Red
POSACONAZOLE Red Severe fungal infections
PRAMIPEXOLE Amber Full SCA Parkinson's Disease, Restless Legs Syndrome and other limb movement disorders

Click on drug name for further details

Full SCA

PRASUGREL Amber Simple ACS where immediate primary percutaneous coronary intervention for ST segment-elevation MI is necessary or stent thrombosis has occurred during clopidogrel treatment.

Excludes pts over 75yrs and /or weight less than 60kg Duration summary for primary care

PREGABALIN Green Neuropathic pain

To be used in conjunction with Neuropathic Pain Guidelines

PREGABALIN Amber Simple Refractory epilepsy

Shared care request is not mandatory
Simple Amber List

PREGABALIN Amber Simple Generalised anxiety disorder

Shared care request is not mandatory
Simple Amber List

PRILOCAINE Red Spinal Anaesthesia
PRO-SIL® Amber Simple Hypertrophic Scars

Shared care request is not mandatory.
Simple Amber List
Includes: Kelocote®, Pro-Sil®, Cica-Care®, Advasil Conform® and Mepiform®
Guidance For Use

PROCARBAZINE Red
PROXYMETACAINE HYDROCHLORIDE Red Local anaesthetic
PRUCALOPRIDE Green Conditional Chronic refractory constipation

To be used in line with
Chronic Constipation Pathway

Chronic Constipation Training

PYRIDOSTIGMINE Amber Simple Myasthenia gravis

Includes sustained release formulation (Mestinon Timespan). Shared care request is not mandatory.
Simple Amber List

QLAIRA® Black Contraception

Not approved by local committee

QUETIAPINE Amber Full SCA Schizophrenia. Mania (either alone or in combination with mood stabilisers). Depression in bipolar disorder. Adjunctive treatment in major depressive disorder. Personality disorder.

Full SCA

Full SCA personality disorder

QUINAGOLIDE Amber Simple Hyperprolactinaemia

Shared care request is not mandatory
Simple Amber List

RACECADOTRIL (Hidrasec®) Black Diarrhoea
RALTEGRAVIR Red
RALTEGRAVIR Red Multi-resistant HIV
RANIBIZUMAB (Lucentis®) Red Age-related macular degeneration, diabetic macular oedema, retinal vein occlusion
RANOLAZINE Green Chronic stable angina

In line with NICE CG 126

RASAGILINE Amber Simple Parkinson's disease

Click on drug name for further details

 

REGORAFENIB Red
REPAGLINIDE Green
RESPERATE device Black Hypertension

Reviewed by Dr A. Stanley, Hypertension Clinic

RETAPAMULIN Black Bacterial skin infections
RETIGABINE Red Treatment resistant epilepsy
RIBAVIRIN Red
RIBOFLAVIN eye drops (NEW) Red Peri-operative use during collagen cross linkage
RIFAMPICIN/ISONIAZID/PYRAZINAMIDE/ETHAMBUTOL (Voractiv) (NEW) Red Tuberculosis
RIFAXIMIN Amber Simple Reduction in recurrence of hepatic encaphalopathy

Shared care request is not mandatory

Simple Amber List

RIFAXIMIN Black Traveller's diarrhoea
RILPIVIRINE Red
RILUZOLE Amber Full SCA Amylotrophic lateral sclerosis form of motor neurone disease

Full SCA

RIMEXOLONE Red
RIOCIGUAT Black Pulmonary hypertension
RISPERIDONE LONG-ACTING INJECTION (Risperdal Consta®) Amber Full SCA Schizophrenia and other psychoses in patients tolerant to oral risperidone.

Full SCA     Request form

RISPERIDONE Oral Amber Full SCA Acute and chronic psychoses. Mania. Short term (up to 6 weeks) of persistent aggression in patients with moderate to severe AD. Short term (up to 6 weeks) treatment of persistent aggression in conduct disorder. Personality disorder.

Full SCA

Full SCA personality disorder

RITONAVIR Red
RITUXIMAB (NEW) Red Immunobullous diseases

In line with NHS England policy

RITUXIMAB Red Lymphoma, Rheumatoid arthritis
RIVAROXABAN Amber Simple Cardioversion
RIVAROXABAN Red ACS

In line with NICE TA 335

RIVAROXABAN Green Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation

Use in line with
Primary Care Initiation Pathway 
UHL Prescribers use 
UHL Initiation Pathway (Secondary Care)

RIVAROXABAN Black Prevention of VTE in adults undergoing hip or knee replacement
RIVAROXABAN (UPDATED) Amber Simple Treatment and secondary prevention of DVT and PE

In line with  NICE TA 261  or  NICE TA 287

RIVASTIGMINE Amber Full SCA Dementia

Full SCA     Request form

ROFLUMILAST (UPDATED) Amber Simple COPD

In line with NICE TA 461

ROMIPLOSTIM (Nplate®) (UPDATED) Red Chronic immune (idiopathic) thrombocytopenic purpura (ITP)

Use in line with NICE TA 221

ROPINIROLE Amber Simple Parkinson's Disease, Restless Legs Syndrome and other limb movement disorders

Click on drug name for further details

ROSIGLITAZONE (Avandia®, Avandamet®) Black Withdrawn
ROSUVASTATIN Green Hypercholesterolaemia
ROTIGOTINE Amber Full SCA Parkinson's disease, Restless Legs Syndrome and other limb movement disorders

Click on drug name for further details

Full SCA

RUFINAMIDE Amber Simple Lennox-Gastaut syndrome in patients aged over 4 years

Shared care request is not mandatory
Simple Amber List

RUXOLITINIB Red
SACUBITRIL / VALSARTAN (Entresto®) (UPDATED) Amber Full SCA Heart failure

Full SCA    Request form

SAFINAMIDE (Xadago®) (NEW) Red Parkinson’s Disease
SAQUINAVIR Red
SATIVEX Black Treatment of spasticity associated with Multiple Sclerosis

EM Policy

SAXAGLIPTIN (Onglyza®) Green Type 2 Diabetes.

Non-formulary choice.

SAXAGLIPTIN / METFORMIN (Komboglyze®) Black Type 2 Diabetes
SECUKINUMAB Red Psoriatic arthritis

In line with NICE TA 445

SECUKINUMAB (NEW) Red Psoriasis

In line with NICE TA 350

SECUKINUMAB (UPDATED) Red Ankylosing spondylitis.

Use in line with NICE TA 407

SELEGILINE Amber Simple Parkinson's disease

Click on drug name for further details

SELEXIPAG (Uptravi®) (NEW) Black Pulmonary arterial hypertension

Not yet reviewed

SERTRALINE Amber Simple Depressive illness in children and young people
SEVELAMER Amber Simple Hyperphosphataemia

Shared care request is not mandatory
Simple Amber List

SILDENAFIL Red Pulmonary arterial hypertension
SILDENAFIL ORAL SUSPENSION (Revatio®) Black Pulmonary artery hypertension
SILICONE GEL / GEL SHEETS Amber Simple Hypertrophic Scars

Shared care request is not mandatory.
Simple Amber List
Includes: Kelocote®, Pro-Sil®, Cica-Care®, Advasil Conform® and Mepiform®
Guidance For Use

SIMEPREVIR Red Hepatitis C
SIROLIMUS Amber Full SCA Immunosuppression post renal transplant

Shared care request is mandatory
Full SCA

SITAGLIPTIN Green Type 2 diabetes

In line with NICE CG 87

SITAGLIPTIN / METFORMIN (Janumet®) Black Type 2 diabetes
SODIUM CHLORIDE 5% preservative free eye drops or 5% ointment (NEW) Amber Simple Ocular lubricants

Use in line with guidance.
Leicestershire Guide to Prescribing Ocular Lubricants

SODIUM CITRATE 10.11% eye drops Red
SODIUM OXYBATE Amber Simple Treatment of cataplexy associated with narcolepsy

Shared care request is not mandatory
Simple Amber List

SODIUM VALPROATE SR (Episenta®) Black Epilepsy

Not approved by local committee

SOFOSBUVIR Red Hepatitis C
SOFOSBUVIR/VELPATASVIR (Epclusa®) (NEW) Red Hepatitis C

In line with NICE TA 430

SOLIFENACIN Green Urinary incontinence
SOLIFENACIN / TAMSULOSIN (Vesomni®) Green Benign prostatic hyperplasia

In line with Male LUTS Pathway

SOMATROPIN (Growth Hormone) Red Growth disorders

New patients supplied through healthcare at home

SORAFENIB Red
SOYBEAN OIL EYE DROPS (Emustil®) Black Ocular lubricant

Not yet reviewed

SPIRONOLACTONE Amber Full SCA Heart failure and hypertension in infants and children

Full SCA

STAVUDINE Black
STRIBILD Red HIV
SUCROFERRIC OXYHYDROXIDE (Velphoro®) (NEW) Red Treatment/prevention of hyperphosphataemia of chronic kidney disease
SUFENTANIL (Zalviso®) sublingual tablets Black Acute post-operative pain

Not yet reviewed

SUGAMMADEX Red Reversal of neuromuscular blockade

Emergency use only.

SULFASALAZINE Amber Full SCA Rheumatological disease

Full SCA     Request form

SULFASALAZINE (NEW) Red Inflammatory Bowel Disease in Paediatrics
SULFASALAZINE ORAL & RECTAL Amber Full SCA Ulcerative colitis and Crohn's disease

Shared care request is mandatory
Full SCA

SULPIRIDE (NEW) Green Conditional Schizophrenia

If for use in schizophrenia or psychoses–to be initiated after discussion with specialist

SUNITINIB Red
SYNVISC® Black Black in ALL indications except for Pain relief in osteoarthritis of shoulder joint (RED)
SYNVISC® Red Pain relief in oesteoarthritis of shoulder joint.
SYSTANE® ULTRA preservative free eye drops (NEW) Amber Simple Ocular lubricants

Use in line with guidance
Leicestershire Guide to Prescribing Ocular Lubricants

TACROLIMUS capsules (Adoport®, Prograf® or Modigraf®) Amber Full SCA Immunosuppression post renal transplant - prescribe by brand name only as different brands are not interchangeable

Shared care request is mandatory
Full SCA

TACROLIMUS capsules (Advagraf®) Black Immunosuppression

Modified-release

TACROLIMUS ointment Green Dermatitis
TACROLIMUS SR (Envarsus®) (NEW) Red Prophylaxis of transplant rejection in adult kidney transplants
TADALAFIL Black Benign prostatic hyperplasia
TADALAFIL (UPDATED) Green Erectile dysfunction

For patients who have not responded to sildenafil or to vardenafil. Daily dose not supported

TADALAFIL (Adcirca®) Black Pulmonary arterial hypertension
TAFLUPROST/TIMOLOL preservative free eye drops (Taptiqom®) Black Glaucoma

Not yet reviewed

TAMSULOSIN capsules Green Benign prostatic hypertrophy
TAMSULOSIN tablets Black Benign prostatic hypertrophy
TAPENTADOL immediate release Black Acute pain
TAPENTADOL sustained release Amber Simple Moderate to severe chronic pain (pain clinic recommendation only)

Shared care request is not mandatory
Simple Amber List

TEDIZOLID PHOSPHATE tablets and infusion (Sivextro®) Black Skin infection

Not yet reviewed

TEDUGLUTIDE injection Black Short bowel syndrome

Not yet reviewed

TEGAFUR / GIMERACIL / OTERACIL Red
TEGAFUR / URACIL Red
TEICOPLANIN Green Cellulitis (in primary care)

To be used in conjunction with the Primary Care Cellulitis Pathway – see Class II page 6

TEICOPLANIN Red All indications except cellulitis in primary care
TEMOZOLOMIDE Red
TENOFOVIR Red
TENOFOVIR / EMTRICITABINE (Truvada®) Red
TENOFOVIR ALAFENAMIDE (Vemlidy®) (NEW) Black Hepatitis B

New formulation
Not yet reviewed

TERIFLUNOMIDE Red Multiple sclerosis

In line with NICE TA 303

TERIPARATIDE Red Osteoporosis
TESTOSTERONE (NEW) Amber Full SCA Replacement therapy in children and adolescents

Full SCA

TESTOSTERONE Amber Full SCA Adult male hypogonadism

Full SCA

TESTOSTERONE (UPDATED) Amber Full SCA Gender reassignment

To be used and monitored in line with guidance/written information from specialist centre consultant/team (nearest clinic is in Nottinghamshire*)
(NB no formal SCA in place but written guidance from specialist)
Gender dysphoria services: a guide for GPs and other healthcare professionals

TESTOSTERONE buccal Black Male hypogonadism
TESTOSTERONE Patches (Intrinsa®) Black Hypoactive sexual desire disorder in women

Not approved by local committee

THALIDOMIDE Black Multiple myeloma
TICAGRELOR Amber Simple Troponin positive Acute Coronary Syndromes in NSTEMI patients

Duration summary for primary care

TIGECYCLINE Red Skin and soft tissue infections
TIMOLOL LA Gel-Forming Eye Drops (NEW) Red Small infantile haemangiomas

In line with GOSH guidance

TIOGUANINE Red
TIOTROPIUM (Braltus Zonda®) (NEW) Green COPD

Use in line with Leicestershire LAMA Prescribing Guide

 

TIOTROPIUM (Spiriva HandiHaler® or Spiriva Respimat®) Green COPD
TIOTROPIUM (Spiriva Respimat®) Amber Simple Asthma
TIOTROPIUM/OLODATEROL (Spiolto Respimat®) (NEW) Green COPD

NEW LABA/LAMA combination product – to be used in line with updated COPD Guidelines

TIPRANAVIR Red HIV infection
TIPRANAVIR Red
TIZANIDINE Amber Full SCA MS spasticity

SCA to be developed. Existing primary care prescribing to continue.

TOBRAMYCIN (Vantobra®) (NEW) Black Chronic pulmonary infection due to Pseudomonas aeruginosa

New formulation
Not yet reviewed

TOBRAMYCIN inhalation Red Cystic fibrosis
TOBRAMYCIN injection Red
TOCILIZUMAB (RoActemra®) Red Juvenile idiopathic arthritis

In line with NICE TA 373

TOCILIZUMAB (RoActemra®) Red Rheumatoid arthritis

In line with NICE Technology Appraisal TA247

Both the intraveneous and subcutaneous preparations are RED

TOLCAPONE Red Parkinson's disease

Treatment algorithm

TOLVAPTAN (Jinarc®) Red Autosomal dominant polycystic kidney disease

In line with NICE TA 358

TOLVAPTAN (Samsca®) Black Hyponatraemia secondary to SIADH
TOPIRAMATE Green Migraine
TOPIRAMATE Amber Simple Epilepsy

Shared care request is not mandatory
Simple Amber List

TOPOTECAN Red
TRAMADOL Green Severe pain

Including SR tablets

TRAMETINIB (Mekinist®) Black Melanoma

Not yet reviewed

TREOSULFAN Red
TRIENTINE (NEW) Red Wilson's disease
TRIFLURIDINE / TIPIRACIL (Lonsurf®) (NEW) Black

Not yet reviewed

TRIFLURIDINE 1% eye drops Red
TRIPLE BROMIDES Black Intractable epileptic seizures

Not approved by local committee

TRIPTORELIN Amber Simple Endometriosis, uterine fibroids
TRIPTORELIN Amber Simple Precocious puberty

GP Guidance

TRIPTORELIN Green Prostatic carcinoma

GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician.

Local guidance

TROSPIUM (immediate release) Green Urinary frequency, urgency and incontinence
TROSPIUM XL Black Urinary incontinence
TYPICAL ORAL ANTIPSYCHOTICS (NEW) Green Conditional See individual entries

If used for schizophrenia or psychoses to be initiated only after diagnosis and advice to use typical antipsychotic has been discussed with specialist (green for other licensed indications)

UBIQUINONE Q10 Black Statin-induced myopathy

Not approved by local committee

ULIPRISTAL ACETATE (ellaOne®) Black Emergency contraception

To be taken within 72 hours (3 days) of unprotected sexual intercourse or contraceptive failure.
Use before 72 hours for patients at high risk of pregnancy restricted to Mr Oloto for trial period.

ULIPRISTAL ACETATE (ellaOne®) Green Emergency contraception

To be taken from between 72 hours (3 days) to 120 hours (5 days) of unprotected sexual intercourse or contraceptive failure. Within the first 72 hours use Levonelle®. (Levonelle® 1500 is available on prescription. Levonelle One Step® can be sold to women over the age of 16 years)

ULIPRISTAL ACETATE (Esmya®) Amber Simple Pre-operative treatment of uterine fibroids.
Review appropriateness of treatment after 3/12
UMECLIDINIUM / VILANTEROL inhaler (Anoro Ellipta®) Black COPD

Not yet reviewed

UMECLIDINIUM inhaler (Incruse Ellipta®) Black COPD

Not yet reviewed

UROFOLLITROPIN(Fostimon®) Red IVF
USTEKINUMAB Red Plaque psoriasis

Supported by NICE

USTEKINUMAB (NEW) Red Crohns

In line with NICE TA 456

USTEKINUMAB (NEW) Red Psoriatic arthritis

NICE TA 340

USTEKINUMAB (NEW) Red Plaque psoriasis in children

In line with NICE TA 455

VALGANCICLOVIR (Valcyte®) Red Cytomegalovirus retinitis
VALPROATE SEMISODIUM (Depakote®) (NEW) Amber Simple Mania in bipolar disorder
VALSARTAN / AMLODIPINE (Exforge®) (NEW) Black Hypertension

Not approved by local committee

VANDETANIB Red
VARENICLINE Green Smoking cessation

Alternative option to NRT or buproprion subject to patient using accredited smoking cessation services

VEDOLIZUMAB (NEW) Red Ulcerative colitis

NICE TA 342

VEMURAFENIB Red
VENLAFAXINE Green Depression - low dose (<300mg)
VENLAFAXINE Amber Full SCA Treatment resistant depression - high dose (≥300mg)

Full SCA     Request form

VILDAGLIPTIN Black Type 2 diabetes
VILDAGLIPTIN / METFORMIN (Eucreas®) Black Type 2 diabetes
VIMOVO® (esomeprazole +naproxen) Black Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis
VINORELBINE Red
VISMODEGIB Red
VITAMINS B AND C INTRAMUSCULAR HIGH POTENCY INJECTION (Pabrinex®) Amber Simple Rapid therapy of severe depletion or malabsorption of the water soluble vitamins B and C in alcoholism

Shared care request is not mandatory. (Simple amber pending further review)
Simple Amber List

VITAMINS B AND C INTRAVENOUS HIGH POTENCY INJECTION (Pabrinex®) Red Rapid therapy of severe depletion or malabsorption of the water soluble vitamins B and C.
VORICONAZOLE Red All indications - High cost drug - use on microbiologist advice only
VORTIOXETINE (UPDATED) Amber Simple Major depressive disorder

Third line option

YASMIN® Green Contraception

NOTE: More expensive, with no evidence of significant advantages, compared to other similar OCs.

ZICONOTIDE Black Severe chronic pain (intrathecal)
ZIDOVUDINE Red
ZOLENDRONIC ACID infusion Red Pagets disease & Osteoporosis
ZONISAMIDE Amber Simple Refractory epilepsy

Shared care request is not mandatory
Simple Amber List

ZOSTAVAX (Varicella zoster vaccine) Black Prevention of shingles and post-herpetic neuralgia. Live vaccine therefore NOT suitable for immunocompromised patients. Do not prescribe on FP10 (black through this route).

Available centrally from 1st Sept 2013 for those aged 70 and 79 years
Public Health advice

ZUCLOPENTHIXOL ACETATE (Clopixol Acuphase®) Red Short-term management of acute psychosis or mania

Refer to Local Area Team letter May 2013

ZUCLOPENTHIXOL DECANOATE (Clopixol® Depot and Clopixol® Conc.) Amber Full SCA Schizophrenia

Full SCA     Request form

ZUCLOPENTHIXOL ORAL (NEW) Green Conditional Schizophrenia and other psychoses

If used for schizophrenia or psychoses to be initiated only after diagnosis and advice to use typical antipsychotic has been discussed with specialist

Traffic Light Classifications

Black

Drugs not recommended for use in the Leicestershire Health Community because of lack of evidence of clinical effectiveness, cost prioritization or concerns over safety.

All new drugs will be black until they have been through the appropriate approval process - then they will appear as a specific entry.

Red

Drugs which should be prescribed only by hospital specialists (clinical review by specialist as appropriate and annually as a minimum).

Amber Full SCA

Drugs which would initially be prescribed by a hospital specialist and then by a GP where full agreement to share the care of each specific patient has been reached under a LMSG Shared Care Agreement (SCA). Specific patient monitoring or intervention required.

Amber Simple

Drugs suitable to be initiated and prescribed in primary care only after specialist assessment and recommendation. A shared care agreement is not required.

Green Conditional

Drugs for which GPs are able to take full responsibility for prescribing and monitoring subject to specified conditions e.g. prescribing in line with agreed LMSG guidance or able to demonstrate suitable competence see comments under individual entries.

Green

Drugs for which GPs would normally take full responsibility for prescribing and monitoring. Drugs included in this list have been specifically considered by LMSG.

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