Leicestershire Traffic Light System
View classifications| Drug Name | Classification | Clinical Indication | Comments |
|---|---|---|---|
| Black | |||
| 5-AMINOLAEVULINIC ACID GEL (Ameluz®) | Black | Actinic keratosis | |
| ABACAVIR / LAMIVUDINE (Kivexa®) | Red | ||
| ABACAVIR/DOLUTEGRAVIR/LAMIVUDINE (Triumeq®) | Red | HIV | |
| ABATACEPT | Red | Rheumatoid arthritis |
In line with NICE TA 195 and NICE TA 280 |
| ABATACEPT | Red | Juvenile idiopathic arthritis |
In line with NICE TA 373 |
| ABIRATERONE | Red | ||
| ACAMPROSATE | Green | Alcohol dependence | |
| ACENOCOUMAROL | Green | Anticoagulation |
For patients currently being treated with phenindione. |
| ACENOCOUMAROL | Red | Anticoagulation |
New patients only. |
| ACETYLCYSTEINE (UPDATED) | Black | Usual interstitial pneumonitis (UIP) |
Click on drug name for further details
|
| ACETYLCYSTEINE 10% preservative free eye drops | Amber Simple | Ocular lubricants |
Use in line with guidance |
| ACITRETIN | Red | ||
| ACLIDINIUM / FORMOTEROL INHALER (Duaklir Genuair®) | Green | COPD |
NEW LABA/LAMA combination product – to be used in line with updated COPD Guidelines |
| ACLIDINIUM INHALER 322 micrograms | Green | COPD |
For patients that cannot manage tiotropium handihaler |
| ACTIKERALL | Green | Actinic keratoses | |
| ADALIMUMAB | Red | Rheumatoid and psoriatic arthritis; ankylosing spondylitis; refractory Crohn's disease |
Added indication: Refractory Crohn’s disease |
| ADALIMUMAB (NEW) | Red | Juvenile idiopathic arthritis |
In line with NICE TA 373 |
| ADALIMUMAB | Red | Psoriasis |
In line with NICE TA 146 |
| ADALIMUMAB | Red | Hidradenitis suppurativa |
In line with NICE TA 392 |
| ADALIMUMAB | Red | Moderate to severe ulcerative colitis |
In line with NICE TA 329 |
| ADALIMUMAB | Red | Behcet’s disease |
Alternative to infliximab once established on therapy. |
| ADAPALENE / BENZOYL PEROXIDE (Epiduo®) | Green | Acne vulgaris | |
| Adios® | Black | Herbal slimming aid | |
| ADVASIL CONFORM® | Amber Simple | Hypertrophic Scars |
Includes: Kelocote®, Pro-Sil®, Cica-Care®, Advasil Conform® and Mepiform® |
| AFATINIB | Red | ||
| AFLIBERCEPT (Eylea®) (UPDATED) | Red | Wet age related macular degeneration. Diabetic macular oedema. Macular oedema due to central retinal vein occlusion and branch retinal vein occlusion. |
Use in line with NICE TA346 |
| Age-Related Macular Degeneration - Dietary Supplements | Black | Age-related macular degeneration (AMD) |
Not approved by local committee see Guideline |
| AGOMELATINE | Amber Full SCA | Depression | |
| ALBIGLUTIDE (Eperzan®) | Black | Type 2 diabetes |
Not yet reviewed |
| ALEMTUZUMAB | Red |
Relapsing, remitting multiple sclerosis |
In line with NICE TA 312 |
| ALENDRONIC ACID + VITAMIN D | Black | Postmenopausal osteoporosis | |
| ALENDRONIC ACID EFFERVESCENT TABLETS (Binosto®) (UPDATED) | Green | Osteoporosis |
For patients that cannot swallow tablets. Not suitable for administration via a feeding tube. |
| ALIROCUMAB Subcutaneous Injection (Praluent®) (UPDATED) | Red | Primary hypercholesterolaemia |
In line with NICE TA 393 |
| ALISKIREN | Amber Full SCA |
Hypertension |
|
| ALITRETINOIN | Red | Severe chronic hand eczema |
In line with NICE TA 177 |
| ALOGLIPTIN | Green | Type 2 diabetes | |
| ALPHA-1 ANTITRYPSIN (Respreeza®) (NEW) | Black | Emphysema in adults |
Not yet reviewed |
| ALPROSTADIL cream (Vitaros®) (UPDATED) | Black | Erectile dysfunction | |
| AMANTADINE | Amber Simple | Parkinson's disease |
Click on drug name for further detail |
| AMIFAMPRIDINE (Firdapse®) | Black | Lambert-Eaton myasthenic syndrome | |
| AMILORIDE | Amber Full SCA | Heart failure and hypertension in infants and children | |
| AMISULPRIDE | Amber Full SCA | Schizophrenia | |
| AMPHOTERICIN 0.15% preservative free eye drops | Red | ||
| ANAGRELIDE | Red | ||
| ANAKINRA | Red | ||
| ANASTROZOLE | Amber Simple | Adjuvant therapy in early breast cancer | |
| ANIDULAFUNGIN | Black | Invasive candidiasis | |
| ANTICANCER DRUGS | Red | Neoplastic disease |
Classified as BLACK or RED unless an exception for shared care (see this list). |
| ANTIPSYCHOTICS-Atypical | Amber Full SCA | All licensed indications, personality disorder | |
| ANTIRETROVIRALS | Red | HIV | |
| ANTITHROMBIN recombinant | Black | Congenital antithrombin deficiency | |
| APIXABAN | Green | Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation |
Use in line with |
| APIXABAN (NEW) | Amber Full SCA | Treatment and secondary prevention of DVT and PE |
In line with NICE TA 341 |
| APOMORPHINE | Red | Parkinson's disease | |
| APRACLONIDINE | Red | Glaucoma | |
| APREMILAST (Otezla®) (NEW) | Red | Psoriasis |
In line with NICE TA 419 |
| APREMILAST (Otezla®) (UPDATED) | Red | Psoriatic arthritis |
In line with NICE TA 433 |
| ARIPIPRAZOLE LONG-ACTING INJECTION (Abilify Maintena®) | Amber Full SCA | Maintenance treatment of schizophrenia in patients currently stabilised on oral aripiprazole | |
| ARIPIPRAZOLE oral | Amber Full SCA | Schizophrenia. Treatment and recurrence of mania. Control of agitation and disturbed behaviour in schizophrenia | |
| ASENAPINE | Black | Manic episodes of bipolar disorder. | |
| ATALUREN (NEW) | Red | Duchenne muscular dystrophy |
In line with NICE HST3 |
| ATAZANAVIR | Red | ||
| ATAZANAVIR / COBICISTAT (Evotaz®) (NEW) | Red | HIV infection | |
| ATOMOXETINE | Amber Full SCA | Attention deficit hyperactivity disorder (ADHD) |
Adults Children and adolescents
|
| ATOVAQUONE | Red | ||
| ATROPINE EYE DROPS | Green Conditional | Palliative care in line with guidance | |
| AVANAFIL | Black | Erectile dysfunction |
Not yet reviewed |
| AVIPTADIL/PHENTOLAMINE intracavernosal injection (Invicorp®) | Black | Erectile dysfunction |
Not yet reviewed |
| AXITINIB | Red | ||
| AZATHIOPRINE | Amber Full SCA | Dermatological disease | |
| AZATHIOPRINE | Amber Full SCA | Paediatric Inflammatory Bowel Disease (Ulcerative Colitis and Crohn's Disease) |
|
| AZATHIOPRINE | Amber Full SCA | Rheumatological disease | |
| AZATHIOPRINE | Amber Full SCA | Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease) & Autoimmune Hepatitis | |
| AZILSARTAN | Black | Hypertension | |
| AZTREONAM | Red | Infection in cystic fibrosis | |
| BALSALAZIDE | Amber Full SCA | Ulcerative colitis | |
| BARICITINIB (Olumiant®) (NEW) | Black | Moderate-to-severe active rheumatoid arthritis in adults who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs – monotherapy or in combination with methotrexate |
Not yet reviewed |
| BECAPLERMIN | Black | ||
| BECLOMETASONE DIPROPIONATE / FORMOTEROL (Fostair®) | Green |
Asthma COPD |
Prescribe in line with Adult Asthma Guideline |
| BECLOMETASONE Inhaler - CFC free | Green | Asthma |
QVAR brand recommended for adults. Clenil Modulite brand recommended only for children. |
| BEDAQUILINE (UPDATED) | Red | Multi-drug resistant tuberculosis | |
| BETAMETHASONE plaster (Betesil®) | Black | Inflammatory skin disorders not responding to less potent corticosteroids |
Not approved by local committee |
| BEXAROTENE | Red | ||
| BEZLOTOXUMAB (Zinplava®) (NEW) | Black | Prevention of recurrence of Clostridium difficile infection |
Not yet reviewed |
| BICALUTAMIDE | Amber Simple | Prostate cancer | |
| BILASTINE | Black | Allergic rhinoconjunctivitis and urticaria | |
| BIMATOPROST / TIMOLOL eye drops (Ganfort®) | Green | Glaucoma |
If prescribed in line with Glaucoma Algorithm |
| BIMATOPROST / TIMOLOL preservative free eye drops (Ganfort UD®) | Green | Glaucoma |
If prescribed in line with Glaucoma Algorithm |
| BIMATOPROST preservative free eye drops | Green | Glaucoma |
If prescribed in line with Glaucoma Algorithm |
| Bio-Oil® | Black | Skincare product | |
| BIOBRAN MGN-3 | Black | Adjuvant to cancer treatment |
Cancer Research UK statement |
| BOSENTAN | Red | Pulmonary hypertension |
Specialist centres only |
| BOSUTINIB | Red | ||
| BOTULINUM TOXIN | Red | Various indications |
Policy in development |
| BOTULINUM A TOXIN | Red | Chronic migraine |
see NICE TA 260 |
| BOTULINUM A TOXIN (Dysport®) (NEW) | Black |
Not yet reviewed |
|
| BRIMONIDINE CUTANEOUS GEL (UPDATED) | Green | Facial erythema of rosacea (fixed erythema not flushing) |
Review after one month and discontinue if no benefit |
| BRINZOLAMIDE / BRIMONIDINE (Simbrinza®) eye drops | Green | Glaucoma |
If prescribed in line with Glaucoma Prescribing Algorithm |
| BRINZOLAMIDE / TIMOLOL (Azarga®) | Green | Glaucoma |
If prescribed in line with Glaucoma Prescribing Algorithm |
| BRIVARACETAM (NEW) | Red | Epilepsy (third line agent) | |
| BROMOCRIPTINE | Amber Full SCA | Hyperprolactinaemic disorders | |
| BUDESONIDE (Budenofalk®) | Amber Simple | Autoimmune hepatitis, Crohn's disease, ulcerative colitis | |
| BUDESONIDE / FORMOTEROL INHALER (DuoResp Spiromax®) | Green | Asthma & COPD |
Prescribe by brand as Budesonide/Formoterol devices not interchangeable. For new patients and existing patients over 18 years after a review by a healthcare professional and counselling of patient to ensure correct use of device |
| BUPRENORPHINE | Green | Severe pain |
including transdermal patch |
| BUSERELIN (Suprecur®) | Red | IVF | |
| BUSULFAN | Red | ||
| CABERGOLINE | Black | Parkinson's disease |
Black for new patients, existing patients to remain on therapy. |
| CABERGOLINE (UPDATED) | Amber Simple | Hyperprolactinaemic disorders | |
| CABERGOLINE (NEW) | Red | Suppression of lactation | |
| CABOZANTINIB tablets (Cabometyx®) (NEW) | Black | Renal cell carcinoma |
Not yet reviewed |
| CALCIPOTRIOL/BETAMETHASONE CUTANEOUS FOAM (Enstilar®) (UPDATED) | Green | Psoriasis vulgaris | |
| CALCITONIN injection | Red |
New patients only |
|
| CANAGLIFLOZIN | Amber Simple | Type 2 diabetes |
Click on drug name for further details |
| CANAGLIFLOZIN | Green Conditional | Type 2 diabetes |
Conditional on prescriber being competent to select appropriate patients. |
| CANAGLIFLOZIN (NEW) | Green | Monotherapy in type 2 diabetes |
In line with NICE TA 390 |
| CANAGLIFLOZIN / METFORMIN (Vokanamet®) | Black | Type 2 diabetes |
Not yet reviewed |
| CANNABIS Derivative (Sativex®) | Black | Multiple sclerosis | |
| CAPECITABINE | Red | ||
| CAPHOSOL® | Red | Oral mucositis in head & neck cancer patients | |
| CAPSAICIN 8% patch (Qutenza®) | Red | Peripheral neuropathic pain |
Only if unresponsive to other treatments in local guidance. |
| CAPSAICIN 8% PATCH (Qutenza®) (NEW) | Black | Diabetic neuropathy | |
| CAPTOPRIL | Amber Full SCA | Heart failure and hypertension in infants and children | |
| CASPOFUNGIN | Red | ||
| CEFIXIME | Green | Gonorrhoea | |
| CEFOTAXIME | Red | ||
| CEFTAROLINE | Red | Confirmed MRSA community acquired pneumonia and complicated skin and soft tissue infections |
On advice of a consultant microbiologist only |
| CEFTAZIDIME | Red | ||
| CEFTAZIDIME / AVIBACTAM (Zavicefta®) (NEW) | Black |
New formulation |
|
| CEFUROXIME 5% eye drops | Red | ||
| CELECOXIB (Onsenal®) | Black | Familial adenomatous polyposis | |
| CERITINIB (Zykadia®) | Black | Lung cancer |
Not yet reviewed |
| CERTOLIZUMAB PEGOL (UPDATED) | Red | Rheumatoid arthritis |
In line with NICE TA 375 and NICE TA 415 |
| CERTOLIZUMAB PEGOL (UPDATED) | Red | Ankylosing spondylitis and non-radiographic axial spondyloarthritis |
In line with NICE TA 383 |
| CERTOLIZUMAB PEGOL (NEW) | Red | Psoriatic arthritis |
In line with NICE TA 445 |
| CETRORELIX (Cetrotide®) | Red | IVF | |
| CHLORAMBUCIL | Red | ||
| CHLORHEXIDINE 2% EYE DROPS | Black | Fungal keratitis |
Not approved by local committee |
| CHLORHEXIDINE GLUCONATE 1% cream (Eczmol®) | Green | Adjunctive therapy for decreasing bacterial load only in cases of recurrent infected atopic eczema in children. | |
| CHLORHEXIDINE GLUCONATE 1% cream (Eczmol®) | Black | Eczema and Dermatitis |
Not approved by local committee |
| CHORIONIC GONADOTROPHIN (Pregnyl®) | Red | IVF | |
| CICA-CARE® | Amber Simple | Hypertrophic Scars |
Shared care request is not mandatory. |
| CICLOSPORIN OPTHALMIC EMULSION (Ikervis®) | Amber Simple | Dry eye disease |
In line with NICE TA 369 |
| CICLOSPORIN Oral | Amber Full SCA | Dermatological disease | |
| CIDOFOVIR | Red | CMV retinitis | |
| CINACALCET | Amber Full SCA | Secondary hyperparathyroidism |
Shared care request is mandatory |
| CINACALCET (NEW) | Red | Primary hyperparathyroidism | |
| CINNARIZINE / DIMENHYDRINATE (Arlevert®) | Amber Simple | Dizziness in Meniere's disease |
Click on drug name for further details |
| CIPROFLOXACIN 0.2% preservative free eye drops | Red | ||
| CIPROFLOXACIN eye ointment | Green | Eye infections |
Second-line to chloramphenicol |
| CITALOPRAM | Amber Simple | Depressive illness in children and young people | |
| Clindamycin plus tretinoin (Treclin®) (NEW) | Green | Acne |
Second choice in line with local algorithm |
| CLOMIPHENE | Red | ||
| CLOZAPINE | Red |
Leicestershire Partnership Trust consultants only |
|
| CO-PROXAMOL (NEW) | Black | Analgesia |
Due to safety concerns |
| Cobicistat (Tybost®) | Red | HIV infection | |
| COBICISTAT / ELVITEGRAVIR / EMTRICITABINE / TENOFOVIR (Stribild) | Red | HIV | |
| COBIMETINIB (Cotellic®) | Black | Melanoma |
Not yet reviewed |
| COLESEVELAM | Black |
Primary and familial hypercholesterolaemia |
Not yet reviewed |
| COLESEVELAM (NEW) | Red | Bile acid malabsorption |
Off label use second line to colestyramine if that is not tolerated. |
| COLESTILAN | Black | Hyperphosphataemia with renal failure |
Following local review |
| COLISTIMETHATE SODIUM (Colobreathe®) INHALATION POWDER | Red | Cystic Fibrosis | |
| COLISTIN | Red | IV for cystic fibrosis | |
| COLISTIN | Amber Full SCA |
Pseudomonas aeruginosa lung infections (Nebulised) |
Shared care request is mandatory |
| COLLAGENASE | Red | ||
| CRIZOTINIB | Red | ||
| CYCLOPHOSPHAMIDE | Red | ||
| DABIGATRAN | Red | Venous thromboembolism (treatment and long term secondary prevention) |
In line with NICE TA 327 |
| DABIGATRAN | Green | Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation |
Use in line with Primary Care Initiation Pathway |
| DABIGATRAN | Red | Prevention of Venous Thromboembolism (VTE) following knee / hip replacement surgery |
In line with NICE TA 157 |
| DABRAFENIB | Red | ||
| DACLATASVIR | Red | Hepatitis C |
In line with NICE TA 364 |
| DACLATASVIR (NEW) | Red | Patients with hepatitis C who have Cirrhosis |
Reviewed by TAS |
| DACLIZUMAB (UPDATED) | Red | Relapsing forms of multiple sclerosis |
In line with NICE TA 441 |
| DALBAVANCIN (Xydalba®) (NEW) | Black | Bacterial skin infections |
Not yet reviewed |
| DALTEPARIN | Green Conditional | Thromboprophylaxis and Treatment of DVT |
Conditional for those prescribers who have received the accredited training currently used in One City.Training |
| DALTEPARIN | Amber Full SCA | Thromboprophylaxis & treatment of DVT |
If prescriber has not received training. Shared care request is mandatory. |
| DAPAGLIFLOZIN (NEW) | Green | Monotherapy in type 2 diabetes |
In line with NICE TA 390 |
| DAPAGLIFLOZIN | Amber Simple | Type 2 diabetes |
Amber if GP does not feel competent to initiate. Use in line with NICE TA 288 |
| DAPAGLIFLOZIN | Green Conditional | Type 2 diabetes |
Conditional on prescriber being competent to select appropriate patients |
| DAPAGLIFLOZIN / METFORMIN (Xigduo®) | Black | Type 2 diabetes |
Not yet reviewed |
| DAPOXETINE | Black | Premature ejaculation |
Not yet reviewed |
| DAPTOMYCIN | Red | Complicated Gram +ve skin/soft tissue infections | |
| DARBEPOETIN | Red | Anaemia of chronic kidney disease | |
| DARIFENACIN | Black | Urinary incontinence/urgency | |
| DARUNAVIR | Red | HIV infection | |
| DARUNAVIR / COBICISTAT (Rezolsta®) (NEW) | Red | HIV infection | |
| DASABUVIR (NEW) | Red | Patients with hepatitis C who have Cirrhosis |
Reviewed by TAS |
| DASATINIB | Red | ||
| DEFERASIROX | Red | Iron overload | |
| DEFERIPRONE | Red | ||
| DEGARELIX | Amber Simple | Treatment of prostate cancer |
Shared care request is not mandatory |
| DENOSUMAB (Prolia®) | Amber Full SCA | Post-menopausal osteoporosis | |
| DENOSUMAB (Xgeva®) | Amber Full SCA | Prevention of skeletal related events in adults with bone metastases from solid tumours other than prostate | |
| DENOSUMAB (Xgeva®) | Red | Prevention of skeletal related events in adults with bone metastases from solid tumours other than prostate |
Red for patients with severe renal impairment (creatinine clearance less than 30ml/min) |
| DEQUALINIUM CHLORIDE VAGINAL TABLETS (Fluomizin®) | Black | Bacterial vaginosis | |
| Dermatix® | Black | Dressing for treatment of scars | |
| DESFERRIOXAMINE | Red | ||
| DESIRUDIN | Red | ||
| DEXAMETHASONE intravitreal implant (UPDATED) | Red | Macular oedema due to retinal vein occlusion |
In line with NICE TA 229 |
| DEXAMFETAMINE | Amber Full SCA | Attention deficit hyperactivity disorder (ADHD) |
Adults Children and adolescents |
| DEXIBUPROFEN | Black | Pain and inflammation | |
| DIAMORPHINE NASAL SPRAY (Ayendi®) | Black | Acute severe pain in children and adolescents |
Not yet reviewed |
| DICLOFENAC GEL 3% (Solaraze®) | Green | Actinic keratosis | |
| DIDANOSINE | Red | ||
| DIMETHYL FUMARATE | Red | Multiple sclerosis |
In line with NICE TA 320
|
| DINOPROSTONE | Red | Induction of labour | |
| DISODIUM PAMIDRONATE | Red | ||
| DISULFIRAM | Amber Simple | Adjunct in alcohol dependence |
Shared care request is not mandatory |
| DOLASETRON | Black | Chemotherapy-induced nausea & vomiting | |
| DOLUTEGRAVIR | Red | HIV | |
| DONEPEZIL | Amber Full SCA | Dementia | |
| DORIPENEM | Black | Nosocomial pneumonia, complicated intra-abdominal and urinary tract infection | |
| DORIPENEM | Red | Hospital acquired/ventilator associated pneumonia | |
| DORNASE ALFA | Amber Simple | Cystic fibrosis | |
| DOXYCYCLINE Controlled release (Efracea®) | Black | Rosacea |
Not approved by local committee |
| DRONEDARONE | Red | Atrial fibrillation |
New patients only |
| DROPERIDOL | Red | Post operative nausea & vomiting |
3rd line |
| DULAGLUTIDE (UPDATED) | Amber Simple | Type 2 Diabetes |
If prescriber has not received specific training. |
| DULAGLUTIDE (UPDATED) | Green Conditional | Type 2 diabetes |
Conditional on prescriber being trained to select and train patients – use in conjunction with updated NICE Clinical Guideline. Once a week preparation. |
| DULOXETINE | Green | Diabetic neuropathy |
To be used in conjunction with Neuropathic Pain Guidelines |
| DULOXETINE | Green | Stress incontinence | |
| DULOXETINE | Red | Fibromyalgia |
For use by Pain Clinic only |
| DUTASTERIDE / TAMSULOSIN (Combodart®) | Green |
Benign Prostatic Hyperplasia when used in line with pathway |
Green if prescribed in line with local Male LUTS pathway |
| EDOXABAN | Red | DVT and PE |
Use in line with NICE TA354 |
| EDOXABAN | Green | Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation |
Use in line with
|
| EFAVIRENZ | Red | ||
| EFAVIRENZ / EMTRICITABINE / TENOFOVIR (Atripla®) | Red | ||
| EFLORNITHINE | Black | Female facial hirsuitism |
Not approved by local committee |
| ELBASVIR/GRAZOPREVIR (Zepatier) (NEW) | Red | Hepatitis C |
In line with NICE TA 413 |
| ELTROMBOPAG | Red | Chronic immune thrombocytopenic purpura (ITP) | |
| ELVITEGRAVIR/COBICISTAT/EMTRICITABINE/TENOFOVIR ALAFENAMIDE (Genvoya®) (NEW) | Red | HIV infection | |
| EMPAGLIFLOZIN (NEW) | Green | Monotherapy in type 2 diabetes |
In line with NICE TA 390 |
| EMPAGLIFLOZIN | Amber Simple | Type 2 diabetes |
Amber if GP does not feel competent to initiate. |
| EMPAGLIFLOZIN | Green Conditional | Type 2 diabetes |
Conditional on prescriber being competent to select appropriate patients |
| EMPAGLIFLOZIN / LINAGLIPTIN (Glyxambi®) (NEW) | Black | Type 2 diabetes mellitus in adults |
New formulation |
| EMPAGLIFLOZIN/METFORMIN (Synjardy®) | Black | Type 2 diabetes |
Not yet reviewed |
| EMTRICITABINE | Red | ||
| EMTRICITABINE / RILPIVIRINE / TENOFOVIR (Eviplera®) | Red | ||
| EMTRICITABINE / RILPIVIRINE / TENOFOVIR ALAFENAMIDE (Odefsey®) (UPDATED) | Red | HIV infection | |
| EMTRICITABINE/TENOFOVIR ALAFENAMIDE (Descovy®) (NEW) | Red | HIV infection | |
| ENALAPRIL | Amber Full SCA | Heart failure and hypertension in infants and children | |
| ENFUVIRTIDE | Red | ||
| ENOXAPARIN | Red | Acute coronary syndrome | |
| ENTACAPONE | Amber Simple | Parkinson's disease |
Click on drug name for further details |
| ENTECAVIR | Red | Chronic hepatitis B | |
| EPISIL® | Red | Oral mucositis in paediatric patients following chemotherapy | |
| EPLERENONE | Green | Post myocardial infarction with proven LVH | |
| EPOETIN DELTA | Black | Anaemia of renal failure | |
| EPOETIN intravenous | Red |
HDU |
|
| EPOETIN subcutaneous | Red | Anaemia of Chronic Kidney Disease | |
| ERDOSTEINE | Black | Mucolytic - acute exacerbation of chronic bronchitis |
Not approved by local committee |
| ERLOTINIB | Red | ||
| ERTAPENEM | Red | Resistant Gram negative infections (ESBL) | |
| ERTAPENEM IV (NEW) | Green | Extended Spectrum Beta Lactamase (ESBL) Urinary Tract Infection (UTI) |
UTI in line with Primary care ESBL Guidance |
| ESCITALOPRAM | Black | All indications except treatment resistant depression and generalised anxiety disorder |
Not approved by local committee |
| ESCITALOPRAM (UPDATED) | Green | Treatment resistant depression and generalised anxiety disorder | |
| ESLICARBAZEPINE (UPDATED) | Amber Simple | Treatment resistant epilepsy | |
| ESTRADIOL / NOMEGESTROL (Zoely®) | Black | Combined oral contraceptive | |
| ESTRAMUSTINE | Red | ||
| ETANERCEPT (NEW) | Red | Juvenile idiopathic arthritis |
In line with NICE TA 373 |
| ETANERCEPT | Red | DMARD for RA, including weekly SC injection | |
| ETANERCEPT | Red | Plaque psoriasis |
In line with NICE TA103 |
| ETELCALCETIDE injection (Parsabiv) (NEW) | Black | Secondary hyperparathyroidism in adult patients with chronic kidney disease on haemodialysis therapy |
Not yet reviewed |
| ETHINYLESTRADIOL / DESOGESTREL (Alenvona®) | Black | Oral contraceptive |
Not yet reviewed |
| ETOPOSIDE | Red | ||
| ETRAVIRINE | Red | ||
| EVENING PRIMROSE OIL (GAMOLENIC ACID) (Epogam® or Efamast®) (NEW) | Black | Cyclical breast pain/mastalgia. Atopic eczema |
No evidence to support use for these indications. |
| EVEROLIMUS | Red | Angiomyolipomas associated with tuberous sclerosis | |
| EVOLOCUMAB subcutaneous injection (Repatha®) (UPDATED) | Red | Primary hypercholesterolaemia or mixed dyslipidaemia |
In line with NICE TA 394 |
| EVRA® patch | Green | Contraception | |
| EXEMESTANE | Amber Simple | Adjuvant therapy in early breast cancer | |
| EXENATIDE (UPDATED) | Amber Simple | Type 2 Diabetes |
If prescriber has not received specific training. Simple Amber List |
| EXENATIDE | Green Conditional | Type 2 diabetes |
Once a week preparation (Bydureon®) is formulary. Conditional on prescriber being trained to select and train patients. Use in conjunction with Updated Nice Clinical Guideline. ————————- Twice daily preparation (Byetta®) is non formulary. However, existing patients may remain on treatment |
| EZETIMIBE | Green | ||
| EZETIMIBE + SIMVASTATIN (Inegy®) | Black | Hypercholesterolaemia | |
| FAMPRIDINE | Black | Multiple Sclerosis | |
| FEBUXOSTAT | Green | Gout (2nd line after allopurinol) |
In line with NICE TA 164 |
| FENTANYL BUCCAL FILM (Breakyl®) | Black | Breakthrough cancer pain in patients already on opioids |
Not yet reviewed |
| FENTANYL intranasal spray | Black | Breakthrough cancer pain | |
| FENTANYL Sublingual (Abstral®) | Green Conditional | Breakthrough cancer pain in patients already on opioids. Palliative care in line with guidance |
Conditional on recommendation from palliative care team. |
| FENTANYL TRANSDERMAL SYSTEM (IONSYS®) | Black | Post-operative pain | |
| FENTICONAZOLE | Black | Vulvovaginal candidiasis | |
| FERUMOXYTOL INJECTION (Rienso®) | Black | Iron deficiency anaemia in chronic kidney disease | |
| FESOTERODINE | Black | Urinary frequency | |
| FIBRINOGEN CONCENTRATE (Human) (FibCLOT®) (NEW) | Black | Treatment and perioperative prophylaxis of bleeding in patients with congenital hypo- or afibrinogenaemia with bleeding tendency |
New formulation |
| FIDAXOMICIN | Amber Simple |
Clostridium difficile infection |
GP can initiate if in line with Community Clostridium difficile Care Pathway |
| FILGRASTIM | Red | ||
| FINGOLIMOD | Red | Multiple Sclerosis |
NICE supported. |
| FLUDARABINE | Red | ||
| FLUNARIZINE (NEW) | Red | Migraine prophylaxis in adults | |
| FLUNARIZINE | Red | Alternating hemiplegia/refractory migraine in children |
Unlicensed |
| FLUOCINOLONE ACETONIDE (Iluvien®) intravitreal implant | Red | Diabetic macular oedema |
In line with NICE TA301 |
| FLUOXETINE | Amber Simple | Depressive illness in children and young people | |
| FLUPENTIXOL (oral) (NEW) | Green Conditional | Schizophrenia and other psychoses |
If used for schizophrenia or psychoses to be initiated only after diagnosis and advice to use this typical antipsychotic has been discussed with specialist |
| FLUPENTIXOL DECANOATE | Amber Full SCA | Schizophrenia | |
| FLUPHENAZINE DECANOATE | Amber Full SCA | Schizophrenia | |
| FLUTICASONE / AZELASTINE NASAL SPRAY (Dymista®) (UPDATED) | Green | Rhinitis |
To be used in line with the Allergic Rhinitis Pathway |
| FLUTICASONE / FORMOTEROL INHALER (Flutiform®) (UPDATED) | Black | Asthma |
Reviewed by LLR Respiratory Prescribing Group, deemed not appropriate for review by TAS |
| FLUTICASONE / VILANTEROL INHALER (Relvar®) (UPDATED) | Black | Asthma |
Reviewed by LLR Respiratory Prescribing Group, deemed not appropriate for review by TAS |
| FLUTICASONE FUROATE (Avamys®) | Green | Allergic rhinitis | |
| FLUTICASONE/ SALMETEROL XINAFOATE INHALER (AirFluSal Forspiro®) (NEW) | Black | COPD and Asthma |
Reviewed by LLR Respiratory Prescribing Group, deemed not appropriate for review by TAS |
| FOLINIC ACID | Red | ||
| FOLLITROPHIN alfa (Gonal-F®) | Red | IVF | |
| FONDAPARINUX | Red | Heparin Induced Thrombocytopenia (HIT) | |
| FOSAMPRENAVIR | Red | ||
| FOSFOMYCIN IV (NEW) | Red | Only in line with advice from UHL microbiology |
Please note that there is a separate traffic light entry for oral Fosfomycin. |
| FOSFOMYCIN Oral (NEW) | Green | Extended Spectrum Beta Lactamase (ESBL) Urinary Tract Infection (UTI) |
UTI in line with Primary care ESBL Guidance. |
| FULVESTRANT | Amber Simple | Oestrogen receptor positive metastatic or locally advanced breast cancer in post menopausal women in whom disease progresses or relapses while on or after other anti oestrogen therapy |
Secondary care will administer first three doses. |
| FUROSEMIDE | Amber Full SCA | Heart failure and hypertension in infants and children | |
| GABAPENTIN | Green | Neuropathic pain |
To be used in conjunction with |
| GALANTAMINE | Red | Alzheimer's disease |
Leicestershire Partnership Trust consultants only |
| GAMMAGLOBULIN | Red | ||
| GANCICLOVIR | Red | ||
| GANCICLOVIR 0.15% EYE GEL | Black | Acute herpetic keratitis |
Only GREEN whilst Aciclovir eye ointment 3% is not available. Definite diagnosis only.To be used in line with local guidance Ganciclovir 0.15% eye gel |
| GEFITINIB | Red | ||
| GENTAMICIN | Red | IV and inhalation | |
| GENTAMICIN 1.5% preservative free eye drops | Red | ||
| GLATIRAMER | Red | Multiple sclerosis |
Not supported by NICE but supported by DoH. |
| GLUCOSAMINE | Black | Osteoarthritis |
In line with LMSG Glucosamine for OA Guidelines |
| GLYCERYL TRINITRATE Ointment 0.4% | Green | Anal fissure | |
| GLYCOPROTEIN IIb/IIIa inhibitors | Red | ||
| GLYCOPYRRONIUM (Sialanar®) (NEW) | Black | Persistent drooling in children and adolescents with neurological conditions, such as cerebral palsy, epilepsy and neurodegenerative diseases |
New formulation |
| GLYCOPYRRONIUM BROMIDE oral solution 1mg/5ml (NEW) | Black | Peptic ulcer (add-on therapy) |
Not yet reviewed |
| GLYCOPYRRONIUM INHALER (Seebri Breezhaler®) | Black | COPD |
Following review by LLR Respiratory Prescribing Group and Therapeutic Advisory Service |
| GOLD salts (UPDATED) | Red | Rheumatoid arthritis |
Red for new patients Full SCA to remain for existing patients |
| GOLIMUMAB | Red | Psoriatic arthritis (PA) and Rheumatoid arthritis(RA)in line with NICE guidance |
PA see NICE TA 220 |
| GOLIMUMAB | Red | Ankylosing spondylitis |
In line with NICE TA 233 |
| GOLIMUMAB (NEW) | Red | Moderate to severe active ulcerative colitis |
In line with NICE TA 329 |
| GONADORELIN ANALOGUES | Green | Prostate cancer |
GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician. |
| GONADORELIN ANALOGUES (NEW) | Amber Simple | Gender reassignment |
Must be prescribed in line with recommendations from specialist. The nearest specialist is Nottingham. |
| GOSERELIN | Green | Prostatic carcinoma |
GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician. |
| GOSERELIN | Amber Simple | Endometriosis, uterine fibroids | |
| GOSERELIN 3.6mg (Zoladex®) (NEW) | Amber Simple | Breast cancer |
Zoladex 3.6mg implant is the only licensed product for breast cancer |
| GRANISETRON | Black | Chemotherapy-induced nausea | |
| GRANISETRON oral and injection | Green Conditional | Palliative care in line with guidance |
Conditional on recommendation from palliative care team. |
| GRANISETRON patch | Black | Chemotherapy-induced nausea |
Not yet reviewed |
| GRASS POLLEN ALLERGEN EXTRACT subcutaneous injection (Pollinex®) (NEW) | Red | Grass pollen allergies | |
| GRASS POLLEN ALLERGEN EXTRACT sublingual (Grazax®) | Amber Full SCA | Grass pollen allergies | |
| GUANFACINE (NEW) | Amber Full SCA | ADHD (click on drug name for more info) |
|
| HALOPERIDOL (oral) (NEW) | Green Conditional | Schizophrenia and psychoses |
If used for schizophrenia or psychoses to be initiated only after diagnosis and advice to use typical antipsychotic has been discussed with specialist |
| HALOPERIDOL DECANOATE | Amber Full SCA | Schizophrenia | |
| HEPARIN | Red | Full IV anticoagulation | |
| HEPARIN SODIUM FLUSH (NEW) | Green | Flushing solution for maintenance of patency of intravenous devices | |
| HEPATITIS C treatments | Red | ||
| HERBAL MEDICINES that are unregistered (NEW) | Black |
Not approved by local committee |
|
| HERBAL MEDICINES with a Marketing Authorisation (NEW) | Black |
Reviewed upon request by a consultant or GP prescribing lead |
|
| HERBAL MEDICINES with a Traditional Herbal Registration (NEW) | Black |
Not approved by local committee |
|
| HOMEOPATHIC MEDICINES | Black |
Not approved by local committee see Position Statement |
|
| HYALURONIC ACID DERIVATIVE (Synvisc®) | Black | Black in all indications EXCEPT for pain relief in osteoarthritis of shoulder joint (RED) | |
| HYALURONIC ACID DERIVATIVE (Synvisc®) | Red | Pain relief in osteoarthritis of shoulder joint. | |
| HYDROCORTISONE 1% / OXYTETRACYCLINE 3% (Terra-Cortril®) | Black | Overgranulation of wounds |
Not approved by local committee |
| HYDROCORTISONE modified release (Plenadren®) | Black |
Hypoadrenalism (once daily dose) |
|
| HYDROXYCARBAMIDE | Amber Full SCA | Myeloproliferative disorders | |
| HYDROXYCHLOROQUINE | Amber Full SCA | Rheumatological disease | |
| IBANDRONIC ACID - IV | Red | Postmenopausal osteoporosis | |
| IBANDRONIC ACID - Oral | Amber Simple | Breast cancer bone metastases |
Shared care request is not mandatory |
| IBANDRONIC ACID Oral monthly | Green | Postmenopausal osteoporosis |
Use only when compliance with oral therapy is an issue |
| ICATIBANT acetate (UPDATED) | Red | Hereditary angioedema | |
| IDARUBICIN | Red | ||
| IDARUCIZUMAB (Praxbind) | Red | Reversal of severe bleeding due to dabigatran | |
| IDEBENONE (Raxone®) (NEW) | Black | Leber’s hereditary optic neuropathy |
Not yet reviewed |
| IDELALISIB | Red | ||
| IDURSULFASE | Black | Hunter syndrome (mucopolysaccharidosis II) | |
| IMATINIB | Red | ||
| IMIPENEM | Red | ||
| IMIQUIMOD CREAM 3.75% (Zyclara®) | Black |
Actinic keratosis of face and scalp |
|
| IMIQUIMOD cream 5% (Aldara®) | Red | Basal cell carcinoma | |
| IMIQUIMOD cream 5% (Aldara®) (NEW) | Green | Actinic keratoses |
In line with Actinic Keratoses treatment pathway |
| IMMUNOGLOBULINS | Red | ||
| INDACATEROL (Breezhaler®) (UPDATED) | Black | COPD |
Reviewed by LLR Respiratory Prescribing Group, deemed not appropriate for review by TAS |
| INDACATEROL / GLYCOPYRRONIUM INHALER (Ultibro Breezhaler®) (UPDATED) | Black | COPD |
Reviewed by LLR Respiratory Prescribing Group, deemed not appropriate for review by TAS |
| INDINAVIR | Black | ||
| INFLIXIMAB | Red | All indications | |
| INGENOL MEBUTATE GEL (Picato®) (UPDATED) | Green |
Actinic keratosis (non hypertrophic) |
|
| INSULIN ASPART (Fiasp®) (NEW) | Black | Type 1 and 2 diabetes mellitus in adults |
New formulation |
| INSULIN DEGLUDEC (Tresiba®) | Green Conditional | Diabetes mellitus in adults |
Conditional on prescriber being trained to select appropriate patients |
| INSULIN DEGLUDEC (Tresiba®) | Amber Simple | Diabetes mellitus in adults |
Shared care request is not mandatory. Simple amber if prescriber has not received specific training. |
| INSULIN DEGLUDEC / LIRAGLUTIDE (combination product) (Xultophy®) (NEW) | Green Conditional | Diabetes |
Conditional on prescriber being trained to select and train patients. |
| INSULIN DEGLUDEC/LIRAGLUTIDE (combination product) (Xultophy®) (NEW) | Amber Simple | Diabetes |
Shared care request is not mandatory For those who have not had the training. |
| INSULIN GLARGINE (Toujeo® 300units per ml) (UPDATED) | Green | Diabetes mellitus in adults |
UKMI – Product Safety Assessment Report |
| INSULIN GLARGINE / LIXISENATIDE (Suliqua®) (NEW) | Black | Type 2 diabetes mellitus in adults |
New formulation |
| INSULIN GLULISINE (Apidra®) | Green | Type 1 and 2 diabetes |
Prescribe by brand name to avoid confusion with insulin glargine. |
| INSULIN LISPRO (Humalog®) U200 (NEW) | Green Conditional | Diabetes Mellitus |
Conditional on prescriber being competent to select appropriate patients |
| INSULIN LISPRO (Humalog®) U200 (NEW) | Amber Simple | Diabetes Mellitus |
Amber if GP does not feel competent to initiate. |
| INTERFERON ALFA | Red | ||
| INTERFERON BETA | Red | ||
| IRON(III) ISOMALTOSIDE 1000 (Diafer®) (NEW) | Red | Iron deficiency (renal use only) | |
| ISAVUCONAZOLE (NEW) | Red | Invasive aspergillosis and mucormycosis | |
| ISOTRETINOIN - Oral | Red | Severe acne | |
| ISOTRETINOIN - Topical | Green | Mild-moderate acne | |
| IVABRADINE | Green | Chronic stable angina |
For patients who cannot tolerate beta blockers |
| IVABRADINE | Amber Simple | Chronic heart failure | |
| IVACAFTOR | Red | Cystic fibrosis | |
| IVERMECTIN CREAM | Green | Moderate to severe papulo-pustula rosacea | |
| IXEKIZUMAB (NEW) | Red | Psoriasis |
In line with NICE TA 442 |
| KELO-COTE® | Amber Simple | Hypertrophic Scars |
Shared care request is not mandatory |
| KETAMINE | Green Conditional | Palliative Care |
Conditional on recommendation from palliative care team. See: Palliative care – drugs for use only after specialist recommendation
|
| KETOCONAZOLE TABLETS | Black | Fungal infections |
Risk of hepatotoxicity outweighs benefit |
| KETOPROFEN / OMEPRAZOLE (Axorid®) | Black | Pain and inflammation for patients at risk of NSAID associated ulcers | |
| KETOROLAC | Green Conditional | Palliative Care |
Conditional on recommendation from palliative care team. See: Palliative care – drugs for use only after specialist recommendation |
| Klean-Prep® | Red | Bowel cleansing | |
| LACOSAMIDE | Amber Simple | Resistant epilepsy |
Shared care request is not mandatory |
| LAMIVUDINE | Red | ||
| LAMIVUDINE / ZIDOVUDINE | Red | ||
| LANREOTIDE (UPDATED) | Red | Neuroendocrine tumours | |
| LANREOTIDE | Red | Acromegaly |
New patients only |
| LANREOTIDE | Green Conditional | Palliative Care |
Link to Palliative Care Guidelines |
| LANTHANUM CARBONATE | Amber Simple | Hyperphosphataemia with renal failure |
Shared care request is not mandatory |
| LAPATINIB | Red | ||
| LATANOPROST preservative free eye drops | Green | Glaucoma |
If prescribed in line with Glaucoma Prescribing Algorithm |
| LECICARBON A® suppositories | Black | Laxative or bowel preparation |
Not yet reviewed |
| LEDIPASVIR/SOFOSBUVIR (Harvoni®) | Red | Hepatitis C |
In line with NICE TA 363 |
| LEFLUNOMIDE | Amber Full SCA | Rheumatological disease | |
| LENOGRASTIM | Red | ||
| LENVATINIB tablets (Kisplyx®) (NEW) | Black | Renal cell carcinoma | |
| LETROZOLE | Amber Simple | Adjuvant therapy in early breast cancer | |
| LEUPRORELIN | Amber Simple | Endometriosis, uterine fibroids | |
| LEUPRORELIN | Green | Prostate cancer (subcutaneous injection for patients at risk of haematoma) |
GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician. |
| LEVETIRACETAM - IV | Red | Epilepsy |
Restricted to patients who are already maintained on the oral preparation |
| LEVETIRACETAM - Oral | Amber Simple | Epilepsy |
Shared care request is not mandatory |
| LEVODOPA/CARBIDOPA infusion (Duodopa) | Red | Parkinson's disease |
Specialist centres only |
| LEVOFLOXACIN Eyedrops - unpreserved | Red | Bacterial keratitis | |
| LEVOFLOXACIN NEBULISER SOLUTION (Quinsair®) (NEW) | Black | Cystic fibrosis |
Not yet reviewed |
| LEVONORGESTREL-RELEASING INTRAUTERINE SYSTEM (Levosert®) (NEW) | Black | Contraception or heavy menstrual bleeding |
Following local review |
| LIDOCAINE patch | Green | Postherpetic neuralgia |
To be used in conjunction with Neuropathic Pain Guidelines |
| LIDOCAINE patch | Green | Focal neuropathic pain |
To be used in conjunction with Neuropathic Pain Guidelines |
| LIDOCAINE/PRILOCAINE cutaneous spray (Fortacin) (NEW) | Black | Primary premature ejaculation |
Not yet reviewed |
| LINACLOTIDE (UPDATED) | Green | Moderate to severe irritable bowel syndrome with constipation |
Links to IBS Pathway |
| LINAGLIPTIN | Green | Type 2 Diabetes | |
| LIOTHYRONINE (NEW) (UPDATED) | Red | Concomitant therapy with thyroxine |
For patients who have hypothyroidism who have had inadequate response to thyroxine alone, in line with guidance |
| LIPEGFILGRASTIM | Black |
Chemotherapy-induced neutropenia |
Not yet reviewed locally |
| LIRAGLUTIDE | Green Conditional | Type 2 diabetes |
For patients unable to tolerate lixisenatide. Conditional on prescriber being trained to select and train patients – Use in conjunction with Updated NICE Clinical Guideline |
| LIRAGLUTIDE (UPDATED) | Amber Simple | Type 2 diabetes |
If prescriber has not received specific training. |
| LIRAGLUTIDE (Saxenda®) (NEW) | Black | Obesity in type 2 diabetes |
Not yet reviewed |
| LISDEXAMFETAMINE DIMESYLATE | Amber Full SCA | ADHD when response to methylphenidate is inadequate |
Adults Children and adolescents |
| LISINOPRIL | Amber Full SCA | Heart failure and hypertension in infants and children | |
| LITHIUM SALTS | Amber Full SCA | Mania, Bipolar Disorder, Recurrent Depression or Aggressive or Self-mutilating behaviour. | |
| LIXISENATIDE | Green Conditional | Type 2 diabetes |
Conditional on prescriber being trained to select and train patients |
| LIXISENATIDE (UPDATED) | Amber Simple | Type 2 diabetes |
If prescriber has not received specific training. |
| LOMITAPIDE | Black | Homozygous familial hypercholesterolaemia |
Not yet reviewed |
| LOMUSTINE | Red | ||
| LOPINAVIR / RITONAVIR (Kaletra®) | Red | ||
| LOSARTAN | Amber Full SCA | Heart failure and hypertension in infants and children | |
| LOTEPREDNOL eye drops (Lotemax®) (NEW) | Red | Post-operative inflammation following ocular surgery | |
| LOXAPINE inhalation powder (Adasuve®) (NEW) | Black | Rapid control of mild-moderate agitation in schizophrenia or bipolar disorder |
Not yet reviewed |
| LUBIPROSTONE (UPDATED) | Green Conditional | Chronic refractory constipation |
To be used in line with |
| LUMACAFTOR /IVACAFTOR (Orkambi®) | Black | Cystic fibrosis |
Not supported by NICE |
| LURASIDONE | Black | Psychosis |
Following LPT Prescribing Group review |
| LURASIDONE (NEW) | Red | Schizophrenia in adults aged 18 years and over. |
For use only in those:- |
| MacuLEH Light® (NEW) | Black | Age-related macular degeneration |
Not approved by local committee see Guideline |
| MAGNESIUM ASPARTATE DIHYDRATE (Magnaspartate®) (NEW) | Amber Simple | Magnesium deficiency |
Licensed preparation now available. This will be used in preference to any unlicensed preparations. Simple Amber List |
| MANNITOL dry powder inhaler | Red | Cystic fibrosis | |
| MARAVIROC | Red | ||
| MEDROXYPROGESTERONE ACETATE DEPOT INJECTION (Sayana Press®) (UPDATED) | Green | Long-term contraception | |
| MELATONIN | Black | Primary insomnia in adults. Circadian asynchrony in elderly institutionalised patients | |
| MELATONIN | Amber Simple | Free running circadian rhythm and delayed sleep phase syndrome |
Shared care request is not mandatory |
| MELATONIN | Red | Learning disability. Huntington's disease. Parkinson's disease. | |
| MELATONIN | Red |
Acute circadian asynchrony in hospitalised patients on ITU, HDU and other care areas |
|
| MELATONIN (doses of 10mg daily or less) | Amber Simple | Sleep disorders children (see comments) continued in adults if proven efficacy in childhood |
Sleep onset insomnia and delayed sleep phase syndrome Shared care request is not mandatory |
| MELATONIN (doses over 10mg daily) | Red | Sleep disorders children (see comments), continued in adults if proven efficacy in childhood |
Sleep onset insomnia and delayed sleep phase syndrome in children |
| MELPHALAN | Red | ||
| MEMANTINE | Amber Full SCA | Dementia | |
| MENOTROPHIN (Menopur®) | Red | IVF | |
| MEPIFORM® | Amber Simple | Hypertrophic Scars |
Shared care request is not mandatory |
| MERCAPTAMINE (Cystadrops®) (NEW) | Black | Corneal cystine crystal deposits in patients aged ≥ two years with cystinosis |
New formulation |
| MERCAPTOPURINE | Amber Full SCA | Paediatric Inflammatory Bowel Disease (Ulcerative Colitis and Crohn's Disease) | |
| MERCAPTOPURINE | Red | Leukaemia | |
| MERCAPTOPURINE | Amber Full SCA | Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease) & Autoimmune Hepatitis | |
| MEROPENEM | Red | ||
| MESALAZINE (Mezavant® XL) | Black | Ulcerative colitis |
Not supported by local committee |
| MESALAZINE ORAL (prescribe by brand) | Amber Full SCA | Ulcerative colitis and Crohn's disease | |
| MESALAZINE RECTAL | Amber Simple | Ulcerative colitis and Crohn's disease | |
| METHADONE 10mg/1ml | Black | All indications |
This is to prevent dosing errors. The 1mg/1ml strength remains available. |
| METHADONE 1mg/1ml | Green Conditional | Palliative care in line with guidance. |
Conditional on recommendation from palliative care team. |
| METHOTREXATE Injection | Red | ||
| METHOTREXATE Oral | Amber Full SCA | Rheumatological disease | |
| METHOTREXATE Oral | Amber Full SCA | Dermatological disease | |
| METHOTREXATE Oral | Red | Severe refractory asthma | |
| METHOTREXATE Oral | Amber Full SCA | Crohn's Disease | |
| METHYLNATREXONE | Green Conditional | Palliative care in line with guidance. |
Conditional on recommendation from palliative care team. |
| METHYLPHENIDATE | Green Conditional | Palliative care in line with guidance |
Conditional on recommendation from palliative care team. |
| METHYLPHENIDATE (+'CR') | Amber Full SCA | Attention deficit hyperactivity disorder (ADHD)- prescribe CR formulation by brand name only |
Adults Children and adolescents |
| MEXILETINE | Red | Ventricular arrhythmia |
New patients. Existing prescribing in primary care to continue. |
| MIANSERIN | Amber Full SCA | Depression | |
| MIDAZOLAM (Buccolam®) | Amber Simple | Status epilepticus | |
| MIDAZOLAM buccal | Green Conditional | Palliative care in line with guidance. |
Conditional on recommendation from palliative care team. See: Palliative care – drugs for use only after specialist recommendation |
| MIDODRINE (NEW) | Amber Simple | Severe orthostatic hypotension |
Licensed product now available |
| MIFEPRISTONE | Red | ||
| MIGLUSTAT | Black | Niemann-Pick type C disease | |
| MIRABEGRON | Green | Symptoms of urinary frequency, urgency and urge incontinence |
In line with Overactive Bladder Pathway |
| MITOTANE | Red | ||
| MODAFINIL | Amber Full SCA | Daytime sleepiness associated with Narcolepsy and existing patients being treated for Daytime Sleepiness associated with Obstructive Sleep Apnoea Syndrome, Idiopathic Hypersomnia & Shift Work Sleep Disorder. | |
| MOLLUDAB® | Black |
Molluscum contagiosum |
Not yet reviewed. |
| MOLOGRAMOSTIN | Red | ||
| MOLUTREX® | Black | Molluscum contagiosum |
Not yet reviewed |
| MOVICOL liquid® | Black | Constipation | |
| MOVICOL® ready to take solution in sachet (NEW) | Black | Constipation |
Not yet reviewed |
| Moviprep® | Red | Prior to endoscopy |
3rd line if intolerant to Klean Prep® |
| MOXIFLOXACIN | Red | Multi-drug resistant tuberculosis | |
| MOXIFLOXACIN | Black | Respiratory tract infections (general) | |
| MUCODIS® | Red | Oral mucositis in head & neck cancer patients | |
| MYCOPHENOLATE | Amber Full SCA | Immunosuppression following renal transplantation | |
| NABILONE | Black | Chemotherapy induced nausea and vomiting | |
| NABILONE | Red | ||
| NALMEFENE | Green | Alcohol dependence |
In line with NICE TA 325 |
| NALOXEGOL (NEW) | Green | Opiod induced constipation |
In line with NICE TA345 |
| NALTREXONE | Red | Pruritus in liver disease |
Unlicensed indication |
| NALTREXONE (NEW) | Amber Simple | Opioid dependence |
To be initiated by specialists for maintenance treatment to help prevent relapse in opioid dependence. |
| NAPROXEN / ESOMEPRAZOLE (Vimovo®) | Black | Osteoarthritis, RA & ankylosing spondylitis | |
| NATALIZUMAB | Red | Rapidly evolving relapsing-remitting multiple sclerosis | |
| Natamycin 5% eye drops (UPDATED) | Red | Fungal keratitis (moulds only) | |
| NEBIVOLOL | Green | Hypertension |
Black for all other indications |
| NEBIVOLOL | Black | All indications excluding hypertension (Green) | |
| NELFINAVIR | Black | ||
| NETUPITANT/PALONOSETRON capsules (Akynzeo®) | Black | Prevention of nausea and vomiting associated with chemotherapy |
Not yet reviewed |
| NEVIRAPINE | Red | ||
| NILOTINIB | Red | ||
| NINTEDANIB (Ofev®) | Red | Idiopathic Pulmonary Fibrosis |
In line with NICE TA 379 |
| NINTEDANIB (Vargatef®) | Black | Lung cancer |
Not yet reviewed |
| NUVARING® | Green | Contraception | |
| OBETICHOLIC ACID (NEW) | Red | Primary Biliary cholangitis |
In line with NICE TA 443 |
| OCRIPLASMIN INJECTION (Jetrea®) | Red | Vitreomacular traction | |
| OCTREOTIDE | Red | Acromegaly |
New patients only |
| OCTREOTIDE | Red | GEP tumours and post-pancreatic surgery | |
| OCTREOTIDE | Green Conditional | Palliative care in line with guidance |
Conditional on recommendation from palliative care team. |
| OLANZAPINE | Green Conditional | Palliative care in line with guidance |
Conditional on recommendation from palliative care team. |
| OLANZAPINE Oral | Amber Full SCA | Schizophrenia. Combination therapy for mania. Preventing recurrence in bipolar disorder. Monotherapy for mania. Control of agitation and disturbed behaviour in schizophrenia or mania. Personality disorder. | |
| OLANZAPINE PAMOATE MONOHYDRATE (Zypadhera®) | Red | Schizophrenia |
Requires case by case consideration by Prescribing Group |
| OLMESARTAN/AMLODIPINE/HYDROCHLOROTHIAZIDE (Sevikar HCT) (NEW) | Black | Non-adherence due to polypharmacy | |
| OLODATEROL INHALER | Black | COPD |
Not yet reviewed |
| OLOPATADINE | Green | Hay fever | |
| OMALIZUMAB | Red | Asthma |
In line with NICE TA 278 |
| OMALIZUMAB (NEW) | Red | Chronic spontaneous urticaria | |
| OMBITASVIR/PARAPREVIR/RITONAVIR (Viekirax®) | Red | Hepatitis C |
In line with NICE TA 365 (with or without dasabuvir) |
| OMEGA-3 ACID ETHYL ESTERS (Dualtis®) | Black | Secondary prevention of MI, hypertriglyceridaemia |
Not yet reviewed |
| OMEGA-3 ACID ETHYL ESTERS (Omacor®) | Amber Simple | Hypertriglyceridaemia |
Shared care request is not mandatory |
| OMEGA-3 ACID ETHYL ESTERS (Omacor®) | Black | Secondary prevention of MI |
Contains Omega-3 acid ethyl esters |
| ONDANSETRON | Green Conditional | Palliative care in line with guidance |
Conditional on recommendation from palliative care team. |
| ONDANSETRON | Red |
Hyperemesis in pregnancy Chemotherapy/radiotherapy induced nausea |
|
| OPICAPONE capsules (Ongentys®) (NEW) | Black | Parkinson's disease |
Not yet reviewed |
| ORLISTAT | Green | ||
| OSIMERTINIB (Tagrisso®) | Black | Non-small-cell lung cancer | |
| OSVAREN® (previously known as REPHOREN®) | Amber Simple | Hyperphosphataemia | |
| OXYBUPROCAINE HYDROCORTISONE | Red | Local anaesthetic | |
| OXYBUTYNIN patch | Green | Symptomatic treatment of urge incontinence in unstable bladder |
For use only in patients who cannot take oral medication See Overactive bladder pathway |
| OXYCODONE / NALOXONE (Targinact®) | Amber Simple | Severe pain in patients with opioid-induced bowel dysfunction | |
| OXYCODONE HYDROCHLORIDE / NALOXONE (combination product) prolonged release tablet (Targinact®) (NEW) | Black | Post colorectal surgery |
Reviewed by TAS – No evidence to support use for this indication. |
| PALIPERIDONE PALMITATE Long-Acting Injection | Amber Full SCA | Maintenance in schizophrenia in patients previously responsive to risperidone. | |
| PALIVIZUMAB | Red | ||
| PALONOSETRON | Black | Nausea and vomiting with chemotherapy | |
| PARACALCITOL | Black | Secondary hyperparathyroidism in renal failure | |
| PASIREOTIDE subcutaneous injection (Signifor®) | Black | Cushing’s disease |
Not yet reviewed |
| PAZOPANIB | Red | ||
| PEGLOTICASE | Black | Gout |
Not supported by NICE |
| PENICILLAMINE (NEW) | Red | Wilson's disease | |
| PENICILLAMINE | Amber Full SCA | Rheumatoid arthritis | |
| PERAMPANEL (Fycompa®) (UPDATED) | Amber Simple | Refractory epilepsy | |
| PERGOLIDE | Amber Simple | Parkinson's disease |
Click on drug name for further details |
| PIMECROLIMUS cream | Green | Dermatitis | |
| PIRFENIDONE (Esbriet®) | Red | Idiopathic pulmonary fibrosis |
Supported only in line with NICE TA 282 |
| PITRESSIN | Red | Myomectomy | |
| PIVMECILLINAM (NEW) | Green | Extended Spectrum Beta Lactamase (ESBL) Urinary Tract Infection (UTI) |
UTI in line with Primary care ESBL Guidance |
| POLIHEXANIDE 0.02% eye drops | Red | ||
| Pollinex Quattro (NEW) | Black | Severe hayfever caused by tree & grass pollen | |
| POMALIDOMIDE | Red | ||
| PONATINIB | Red | ||
| POSACONAZOLE | Red | Severe fungal infections | |
| PRAMIPEXOLE | Amber Full SCA | Parkinson's Disease, Restless Legs Syndrome and other limb movement disorders |
Click on drug name for further details |
| PRASUGREL | Amber Simple | ACS where immediate primary percutaneous coronary intervention for ST segment-elevation MI is necessary or stent thrombosis has occurred during clopidogrel treatment. |
Excludes pts over 75yrs and /or weight less than 60kg Duration summary for primary care |
| PREGABALIN | Green | Neuropathic pain |
To be used in conjunction with Neuropathic Pain Guidelines |
| PREGABALIN | Amber Simple | Refractory epilepsy |
Shared care request is not mandatory |
| PREGABALIN | Amber Simple | Generalised anxiety disorder |
Shared care request is not mandatory |
| PRILOCAINE | Red | Spinal Anaesthesia | |
| PRO-SIL® | Amber Simple | Hypertrophic Scars |
Shared care request is not mandatory. |
| PROCARBAZINE | Red | ||
| PROXYMETACAINE HYDROCHLORIDE | Red | Local anaesthetic | |
| PRUCALOPRIDE | Green Conditional | Chronic refractory constipation |
To be used in line with |
| PYRIDOSTIGMINE | Amber Simple | Myasthenia gravis |
Includes sustained release formulation (Mestinon Timespan). Shared care request is not mandatory. |
| QLAIRA® | Black | Contraception |
Not approved by local committee |
| QUETIAPINE | Amber Full SCA | Schizophrenia. Mania (either alone or in combination with mood stabilisers). Depression in bipolar disorder. Adjunctive treatment in major depressive disorder. Personality disorder. | |
| QUINAGOLIDE | Amber Simple | Hyperprolactinaemia |
Shared care request is not mandatory |
| RACECADOTRIL (Hidrasec®) | Black | Diarrhoea | |
| RALTEGRAVIR | Red | ||
| RALTEGRAVIR | Red | Multi-resistant HIV | |
| RANIBIZUMAB (Lucentis®) | Red | Age-related macular degeneration, diabetic macular oedema, retinal vein occlusion | |
| RANOLAZINE | Green | Chronic stable angina |
In line with NICE CG 126 |
| RASAGILINE | Amber Simple | Parkinson's disease |
Click on drug name for further details
|
| REGORAFENIB | Red | ||
| REPAGLINIDE | Green | ||
| RESPERATE device | Black | Hypertension |
Reviewed by Dr A. Stanley, Hypertension Clinic |
| RETAPAMULIN | Black | Bacterial skin infections | |
| RETIGABINE | Red | Treatment resistant epilepsy | |
| RIBAVIRIN | Red | ||
| RIBOFLAVIN eye drops (NEW) | Red | Peri-operative use during collagen cross linkage | |
| RIFAMPICIN/ISONIAZID/PYRAZINAMIDE/ETHAMBUTOL (Voractiv) (NEW) | Red | Tuberculosis | |
| RIFAXIMIN | Amber Simple | Reduction in recurrence of hepatic encaphalopathy |
Shared care request is not mandatory |
| RIFAXIMIN | Black | Traveller's diarrhoea | |
| RILPIVIRINE | Red | ||
| RILUZOLE | Amber Full SCA | Amylotrophic lateral sclerosis form of motor neurone disease | |
| RIMEXOLONE | Red | ||
| RIOCIGUAT | Black | Pulmonary hypertension | |
| RISPERIDONE LONG-ACTING INJECTION (Risperdal Consta®) | Amber Full SCA | Schizophrenia and other psychoses in patients tolerant to oral risperidone. | |
| RISPERIDONE Oral | Amber Full SCA | Acute and chronic psychoses. Mania. Short term (up to 6 weeks) of persistent aggression in patients with moderate to severe AD. Short term (up to 6 weeks) treatment of persistent aggression in conduct disorder. Personality disorder. | |
| RITONAVIR | Red | ||
| RITUXIMAB (NEW) | Red | Immunobullous diseases |
In line with NHS England policy |
| RITUXIMAB | Red | Lymphoma, Rheumatoid arthritis | |
| RIVAROXABAN | Amber Simple | Cardioversion | |
| RIVAROXABAN | Red | ACS |
In line with NICE TA 335 |
| RIVAROXABAN | Green | Prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation |
Use in line with |
| RIVAROXABAN | Black | Prevention of VTE in adults undergoing hip or knee replacement | |
| RIVAROXABAN | Amber Full SCA | Treatment and secondary prevention of DVT and PE |
In line with NICE TA 261 or NICE TA 287 |
| RIVASTIGMINE | Amber Full SCA | Dementia | |
| ROFLUMILAST | Black | COPD | |
| ROMIPLOSTIM (Nplate®) (UPDATED) | Red | Chronic immune (idiopathic) thrombocytopenic purpura (ITP) |
Use in line with NICE TA 221 |
| ROPINIROLE | Amber Simple | Parkinson's Disease, Restless Legs Syndrome and other limb movement disorders |
Click on drug name for further details |
| ROSIGLITAZONE (Avandia®, Avandamet®) | Black | Withdrawn | |
| ROSUVASTATIN | Green | Hypercholesterolaemia | |
| ROTIGOTINE | Amber Full SCA | Parkinson's disease, Restless Legs Syndrome and other limb movement disorders |
Click on drug name for further details |
| RUFINAMIDE | Amber Simple | Lennox-Gastaut syndrome in patients aged over 4 years |
Shared care request is not mandatory |
| RUXOLITINIB | Red | ||
| SACUBITRIL / VALSARTAN (Entresto®) (UPDATED) | Amber Full SCA | Heart failure | |
| SAFINAMIDE (Xadago®) (NEW) | Red | Parkinson’s Disease | |
| SAQUINAVIR | Red | ||
| SATIVEX | Black | Treatment of spasticity associated with Multiple Sclerosis | |
| SAXAGLIPTIN (Onglyza®) | Green | Type 2 Diabetes. |
Non-formulary choice. |
| SAXAGLIPTIN / METFORMIN (Komboglyze®) | Black | Type 2 Diabetes | |
| SECUKINUMAB | Red | Psoriatic arthritis |
In line with NICE TA 445 |
| SECUKINUMAB (NEW) | Red | Psoriasis |
In line with NICE TA 350 |
| SECUKINUMAB (UPDATED) | Red | Ankylosing spondylitis. |
Use in line with NICE TA 407 |
| SELEGILINE | Amber Simple | Parkinson's disease |
Click on drug name for further details |
| SELEXIPAG (Uptravi®) (NEW) | Black | Pulmonary arterial hypertension |
Not yet reviewed |
| SERTRALINE | Amber Simple | Depressive illness in children and young people | |
| SEVELAMER | Amber Simple | Hyperphosphataemia |
Shared care request is not mandatory |
| SILDENAFIL | Red | Pulmonary arterial hypertension | |
| SILDENAFIL ORAL SUSPENSION (Revatio®) | Black |
Pulmonary artery hypertension |
|
| SILICONE GEL / GEL SHEETS | Amber Simple | Hypertrophic Scars |
Shared care request is not mandatory. |
| SIMEPREVIR | Red | Hepatitis C | |
| SIROLIMUS | Amber Full SCA | Immunosuppression post renal transplant |
Shared care request is mandatory |
| SITAGLIPTIN | Green | Type 2 diabetes |
In line with NICE CG 87 |
| SITAGLIPTIN / METFORMIN (Janumet®) | Black | Type 2 diabetes | |
| SODIUM CHLORIDE 5% preservative free eye drops or 5% ointment (NEW) | Amber Simple | Ocular lubricants |
Use in line with guidance. |
| SODIUM CITRATE 10.11% eye drops | Red | ||
| SODIUM OXYBATE | Amber Simple | Treatment of cataplexy associated with narcolepsy |
Shared care request is not mandatory |
| SODIUM VALPROATE SR (Episenta®) | Black | Epilepsy |
Not approved by local committee |
| SOFOSBUVIR | Red | Hepatitis C | |
| SOFOSBUVIR/VELPATASVIR (Epclusa®) (NEW) | Red | Hepatitis C |
In line with NICE TA 430 |
| SOLIFENACIN | Green | Urinary incontinence | |
| SOLIFENACIN / TAMSULOSIN (Vesomni®) | Green | Benign prostatic hyperplasia |
In line with Male LUTS Pathway |
| SOMATROPIN (Growth Hormone) | Red | Growth disorders |
New patients supplied through healthcare at home |
| SORAFENIB | Red | ||
| SOYBEAN OIL EYE DROPS (Emustil®) | Black | Ocular lubricant |
Not yet reviewed |
| SPIRONOLACTONE | Amber Full SCA | Heart failure and hypertension in infants and children | |
| STAVUDINE | Black | ||
| STRIBILD | Red | HIV | |
| SUCROFERRIC OXYHYDROXIDE (Velphoro®) (NEW) | Red | Treatment/prevention of hyperphosphataemia of chronic kidney disease | |
| SUFENTANIL (Zalviso®) sublingual tablets | Black | Acute post-operative pain |
Not yet reviewed |
| SUGAMMADEX | Red | Reversal of neuromuscular blockade |
Emergency use only. |
| SULFASALAZINE | Amber Full SCA | Rheumatological disease | |
| SULFASALAZINE (NEW) | Red | Inflammatory Bowel Disease in Paediatrics | |
| SULFASALAZINE ORAL & RECTAL | Amber Full SCA | Ulcerative colitis and Crohn's disease |
Shared care request is mandatory |
| SULPIRIDE (NEW) | Green Conditional | Schizophrenia |
If for use in schizophrenia or psychoses–to be initiated after discussion with specialist |
| SUNITINIB | Red | ||
| SYNVISC® | Black | Black in ALL indications except for Pain relief in osteoarthritis of shoulder joint (RED) | |
| SYNVISC® | Red | Pain relief in oesteoarthritis of shoulder joint. | |
| SYSTANE® ULTRA preservative free eye drops (NEW) | Amber Simple | Ocular lubricants |
Use in line with guidance |
| TACROLIMUS capsules (Adoport®, Prograf® or Modigraf®) | Amber Full SCA | Immunosuppression post renal transplant - prescribe by brand name only as different brands are not interchangeable |
Shared care request is mandatory |
| TACROLIMUS capsules (Advagraf®) | Black | Immunosuppression |
Modified-release |
| TACROLIMUS ointment | Green | Dermatitis | |
| TADALAFIL | Black | Benign prostatic hyperplasia | |
| TADALAFIL (UPDATED) | Green | Erectile dysfunction |
For patients who have not responded to sildenafil or to vardenafil. Daily dose not supported |
| TADALAFIL (Adcirca®) | Black | Pulmonary arterial hypertension | |
| TAFLUPROST/TIMOLOL preservative free eye drops (Taptiqom®) | Black | Glaucoma |
Not yet reviewed |
| TAMSULOSIN capsules | Green | Benign prostatic hypertrophy | |
| TAMSULOSIN tablets | Black | Benign prostatic hypertrophy | |
| TAPENTADOL immediate release | Black | Acute pain | |
| TAPENTADOL sustained release | Amber Simple | Moderate to severe chronic pain (pain clinic recommendation only) |
Shared care request is not mandatory |
| TEDIZOLID PHOSPHATE tablets and infusion (Sivextro®) | Black | Skin infection |
Not yet reviewed |
| TEDUGLUTIDE injection | Black | Short bowel syndrome |
Not yet reviewed |
| TEGAFUR / GIMERACIL / OTERACIL | Red | ||
| TEGAFUR / URACIL | Red | ||
| TEICOPLANIN | Green | Cellulitis (in primary care) |
To be used in conjunction with the Primary Care Cellulitis Pathway – see Class II page 6 |
| TEICOPLANIN | Red | All indications except cellulitis in primary care | |
| TEMOZOLOMIDE | Red | ||
| TENOFOVIR | Red | ||
| TENOFOVIR / EMTRICITABINE (Truvada®) | Red | ||
| TENOFOVIR ALAFENAMIDE (Vemlidy®) (NEW) | Black | Hepatitis B |
New formulation |
| TERIFLUNOMIDE | Red | Multiple sclerosis |
In line with NICE TA 303 |
| TERIPARATIDE | Red | Osteoporosis | |
| TESTOSTERONE (NEW) | Amber Full SCA | Replacement therapy in children and adolescents | |
| TESTOSTERONE | Amber Full SCA | Adult male hypogonadism | |
| TESTOSTERONE (UPDATED) | Amber Full SCA | Gender reassignment |
To be used and monitored in line with guidance/written information from specialist centre consultant/team (nearest clinic is in Nottinghamshire*) |
| TESTOSTERONE buccal | Black | Male hypogonadism | |
| TESTOSTERONE Patches (Intrinsa®) | Black | Hypoactive sexual desire disorder in women |
Not approved by local committee |
| THALIDOMIDE | Black | Multiple myeloma | |
| TICAGRELOR | Amber Simple | Troponin positive Acute Coronary Syndromes in NSTEMI patients |
Duration summary for primary care |
| TIGECYCLINE | Red | Skin and soft tissue infections | |
| TIMOLOL LA Gel-Forming Eye Drops (NEW) | Red | Small infantile haemangiomas |
In line with GOSH guidance |
| TIOGUANINE | Red | ||
| TIOTROPIUM (Spiriva HandiHaler® or Spiriva Respimat®) | Green | COPD | |
| TIOTROPIUM (Spiriva Respimat®) | Amber Simple | Asthma | |
| TIOTROPIUM/OLODATEROL (Spiolto Respimat®) (NEW) | Green | COPD |
NEW LABA/LAMA combination product – to be used in line with updated COPD Guidelines |
| TIPRANAVIR | Red | HIV infection | |
| TIPRANAVIR | Red | ||
| TIZANIDINE | Amber Full SCA | MS spasticity |
SCA to be developed. Existing primary care prescribing to continue. |
| TOBRAMYCIN (Vantobra®) (NEW) | Black | Chronic pulmonary infection due to Pseudomonas aeruginosa |
New formulation |
| TOBRAMYCIN inhalation | Red | Cystic fibrosis | |
| TOBRAMYCIN injection | Red | ||
| TOCILIZUMAB (RoActemra®) | Red | Juvenile idiopathic arthritis |
In line with NICE TA 373 |
| TOCILIZUMAB (RoActemra®) | Red | Rheumatoid arthritis |
In line with NICE Technology Appraisal TA247 Both the intraveneous and subcutaneous preparations are RED |
| TOLCAPONE | Red | Parkinson's disease | |
| TOLVAPTAN (Jinarc®) | Red | Autosomal dominant polycystic kidney disease |
In line with NICE TA 358 |
| TOLVAPTAN (Samsca®) | Black | Hyponatraemia secondary to SIADH | |
| TOPIRAMATE | Green | Migraine | |
| TOPIRAMATE | Amber Simple | Epilepsy |
Shared care request is not mandatory |
| TOPOTECAN | Red | ||
| TRAMADOL | Green | Severe pain |
Including SR tablets |
| TRAMETINIB (Mekinist®) | Black | Melanoma |
Not yet reviewed |
| TREOSULFAN | Red | ||
| TRIENTINE (NEW) | Red | Wilson's disease | |
| TRIFLURIDINE / TIPIRACIL (Lonsurf®) (NEW) | Black |
Not yet reviewed |
|
| TRIFLURIDINE 1% eye drops | Red | ||
| TRIPLE BROMIDES | Black | Intractable epileptic seizures |
Not approved by local committee |
| TRIPTORELIN | Amber Simple | Endometriosis, uterine fibroids | |
| TRIPTORELIN | Amber Simple | Precocious puberty | |
| TRIPTORELIN | Green | Prostatic carcinoma |
GP can give first injection to patients in whom anti-androgen treatment has been started by secondary care clinician. |
| TROSPIUM (immediate release) | Green | Urinary frequency, urgency and incontinence | |
| TROSPIUM XL | Black | Urinary incontinence | |
| TYPICAL ORAL ANTIPSYCHOTICS (NEW) | Green Conditional | See individual entries |
If used for schizophrenia or psychoses to be initiated only after diagnosis and advice to use typical antipsychotic has been discussed with specialist (green for other licensed indications) |
| UBIQUINONE Q10 | Black | Statin-induced myopathy |
Not approved by local committee |
| ULIPRISTAL ACETATE (ellaOne®) | Black | Emergency contraception |
To be taken within 72 hours (3 days) of unprotected sexual intercourse or contraceptive failure. |
| ULIPRISTAL ACETATE (ellaOne®) | Green | Emergency contraception |
To be taken from between 72 hours (3 days) to 120 hours (5 days) of unprotected sexual intercourse or contraceptive failure. Within the first 72 hours use Levonelle®. (Levonelle® 1500 is available on prescription. Levonelle One Step® can be sold to women over the age of 16 years)
|
| ULIPRISTAL ACETATE (Esmya®) | Amber Simple |
Pre-operative treatment of uterine fibroids. Review appropriateness of treatment after 3/12 |
|
| UMECLIDINIUM / VILANTEROL inhaler (Anoro Ellipta®) | Black | COPD |
Not yet reviewed |
| UMECLIDINIUM inhaler (Incruse Ellipta®) | Black | COPD |
Not yet reviewed |
| UROFOLLITROPIN(Fostimon®) | Red | IVF | |
| USTEKINUMAB | Red | Plaque psoriasis |
Supported by NICE |
| USTEKINUMAB (NEW) | Red | Psoriatic arthritis | |
| VALGANCICLOVIR (Valcyte®) | Red | Cytomegalovirus retinitis | |
| VALSARTAN / AMLODIPINE (Exforge®) (NEW) | Black | Hypertension |
Not approved by local committee |
| VANDETANIB | Red | ||
| VARENICLINE | Green | Smoking cessation |
Alternative option to NRT or buproprion subject to patient using accredited smoking cessation services |
| VEDOLIZUMAB (NEW) | Red | Ulcerative colitis | |
| VEMURAFENIB | Red | ||
| VENLAFAXINE | Green | Depression - low dose (<300mg) | |
| VENLAFAXINE | Amber Full SCA | Treatment resistant depression - high dose (≥300mg) | |
| VILDAGLIPTIN | Black | Type 2 diabetes | |
| VILDAGLIPTIN / METFORMIN (Eucreas®) | Black | Type 2 diabetes | |
| VIMOVO® (esomeprazole +naproxen) | Black | Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis | |
| VINORELBINE | Red | ||
| VISMODEGIB | Red | ||
| VITAMINS B AND C INTRAMUSCULAR HIGH POTENCY INJECTION (Pabrinex®) | Amber Simple | Rapid therapy of severe depletion or malabsorption of the water soluble vitamins B and C in alcoholism |
Shared care request is not mandatory. (Simple amber pending further review) |
| VITAMINS B AND C INTRAVENOUS HIGH POTENCY INJECTION (Pabrinex®) | Red | Rapid therapy of severe depletion or malabsorption of the water soluble vitamins B and C. | |
| VORICONAZOLE | Red | All indications - High cost drug - use on microbiologist advice only | |
| VORTIOXETINE (UPDATED) | Amber Simple | Major depressive disorder |
Third line option |
| YASMIN® | Green | Contraception |
NOTE: More expensive, with no evidence of significant advantages, compared to other similar OCs. |
| ZICONOTIDE | Black | Severe chronic pain (intrathecal) | |
| ZIDOVUDINE | Red | ||
| ZOLENDRONIC ACID infusion | Red | Pagets disease & Osteoporosis | |
| ZONISAMIDE | Amber Simple | Refractory epilepsy |
Shared care request is not mandatory |
| ZOSTAVAX (Varicella zoster vaccine) | Black | Prevention of shingles and post-herpetic neuralgia. Live vaccine therefore NOT suitable for immunocompromised patients. Do not prescribe on FP10 (black through this route). |
Available centrally from 1st Sept 2013 for those aged 70 and 79 years |
| ZUCLOPENTHIXOL ACETATE (Clopixol Acuphase®) | Red | Short-term management of acute psychosis or mania |
Refer to Local Area Team letter May 2013 |
| ZUCLOPENTHIXOL DECANOATE (Clopixol® Depot and Clopixol® Conc.) | Amber Full SCA | Schizophrenia | |
| ZUCLOPENTHIXOL ORAL (NEW) | Green Conditional | Schizophrenia and other psychoses |
If used for schizophrenia or psychoses to be initiated only after diagnosis and advice to use typical antipsychotic has been discussed with specialist |
Traffic Light Classifications
Black
Drugs not recommended for use in the Leicestershire Health Community because of lack of evidence of clinical effectiveness, cost prioritization or concerns over safety.
All new drugs will be black until they have been through the appropriate approval process - then they will appear as a specific entry.
Red
Drugs which should be prescribed only by hospital specialists (clinical review by specialist as appropriate and annually as a minimum).
Amber Full SCA
Drugs which would initially be prescribed by a hospital specialist and then by a GP where full agreement to share the care of each specific patient has been reached under a LMSG Shared Care Agreement (SCA). Specific patient monitoring or intervention required.
Amber Simple
Drugs suitable to be initiated and prescribed in primary care only after specialist assessment and recommendation. A shared care agreement is not required.
Green Conditional
Drugs for which GPs are able to take full responsibility for prescribing and monitoring subject to specified conditions e.g. prescribing in line with agreed LMSG guidance or able to demonstrate suitable competence see comments under individual entries.
Green
Drugs for which GPs would normally take full responsibility for prescribing and monitoring. Drugs included in this list have been specifically considered by LMSG.